Paediatric bacterial meningitis is a serious infection that can result in permanent neurological sequelae or death. Broad-spectrum intravenous antibiotics, started as soon as the condition is suspected, are the mainstay of treatment. Acute resuscitation may also be necessary for patients who are in septic shock. Corticosteroids, careful fluid management and advances in intensive care therapy ha...

364 www.thelancet.com/infection Vol 14 May 2014 13-valent pneumococcal vaccines have substantially reduced meningitis and septicaemia in children. Comprehensive disease surveillance with continued development and implementation of vaccines against additional pneumococcal serotypes and serogroup B meningococcal disease will be needed to further improve control of these serious bacterial infections.

Serial C-reactive protein (CRP) measurements appear to be helpful in following clinical course and response to treatment of serious bacterial infections in neonates, such as meningitis, septicaemia and osteomyelitis. In previous studies, serial determination of serum CRP could detect potential complications of meningitis, such as subdural effusion, purulent arthritis and osteomyelitis, and seco...

INTRODUCTION Serious bacterial infections continue to be an important cause of death and illness among infants in developing countries. Time to recovery could be considered a surrogate marker of severity of the infection. We therefore aimed to identify clinical and laboratory predictors of time to recovery in infants with probable serious bacterial infection (PSBI). METHODS We used the datase...

Ceftazidime, a new broad-spectrum cephalosporin, was administered to 30 patients with serious bacterial infections in a randomized dosing trial with daily doses of 1.5 or 3 g. Both regimens were equally efficacious, with satisfactory clinical responses in 28 instances (93%) and microbiological eradication of 79% of initial bacterial isolates. The development of resistance to ceftazidime during ...

Throughout the history of mankind, infectious diseases have remained a major cause of death and disability. Although industrialized nations, such as the United States, have experienced significant reductions in infection-related mortality and morbidity since the beginning of the "antibiotic era," death and complications from infectious diseases remain a serious problem for older persons. Pneumo...

introduction: the purpose of this in vitro study was to compare the ability of triple antibiotic paste (tap) to calcium hydroxide (ch) in disinfecting dentinal tubules. material and methods: sixty root blocks were obtained from extracted single-rooted human teeth. the root canals were enlarged with gates-glidden drills up to size 3 and were contaminated with enterococcus. faecalis ( e. faecalis...

IMPORTANCE The procalcitonin (PCT) assay is an accurate screening test for identifying invasive bacterial infection (IBI); however, data on the PCT assay in very young infants are insufficient. OBJECTIVE To assess the diagnostic characteristics of the PCT assay for detecting serious bacterial infection (SBI) and IBI in febrile infants aged 7 to 91 days. DESIGN, SETTING, AND PARTICIPANTS A p...

OBJECTIVE The goal of this study was to evaluate provider practice patterns for evaluation of serious bacterial infection (SBI) in patients hospitalized with bronchiolitis and to assess the association of SBI testing with length of stay and antibiotic use. DESIGN This was a retrospective chart review of hospitalized patients <24 months of age with a discharge diagnosis of bronchiolitis from 2...