Prolonged use of controlled substances can place patients at increased risk dependence and complications. Women who have mastectomy reconstructive surgery (M + R) may be vulnerable to becoming new persistent users (NPUs) opioid sedative-hypnotic medications. Using the MarketScan health-care claims database, we identified opioid- sedative-hypnotic-naïve women had M R from 2008 2017. filled ≥ 1 p...

population. Current pharmacological approaches focus primarily on the g-aminobutyric acid (GABA)-ergic system, the major inhibitory neurotransmitter system of the central nervous system (CNS). Drugs that enhance synaptic GABA-ergic neurotransmission are widely utilized in the clinical setting for their sedative or hypnotic effects. Several classes of compounds—GABA, benzodiazepines, barbiturate...

background sleep disorders are accompanied by several complications, and currently used soporific drugs can induce unwanted effects such as psychomotor impairment, tolerance, amnesia, and rebound insomnia. results hae increased the duration of pentobarbital-induced sleep at doses of 25, 50, and 100 mg/kg (p < 0.001). the hypnotic effect of hae was comparable to that induced by diazepam. similar...

In this study, we focused on the neuro-behavioral profile, toxicity, and ‎possible mechanisms of action of ‎ Dorema ammoniacum gum essential oil (DAG-EO). For this purpose, passive avoidance and Y-maze tests were performed to evaluate the potential effect ‎of DAG-EO in the attenuation of memory impairment induced by 49 days administration of D-‎galactose and acute injection of scopolam...

BACKGROUND Time-trend studies on psychotropic drugs among children and adolescents are scarce, and most of them are outdated. The purpose of this study was to study prevalences of psychotropic drug use during 2004-2014 among Norwegians aged <18 years, overall and in psychotropic sub-groups. METHODS Data were obtained from the Norwegian Prescription Database, which covers all dispensed prescri...

In this study, we focused on the neuro-behavioral profile, toxicity, and ‎possible mechanisms of action of ‎ Dorema ammoniacum gum essential oil (DAG-EO). For this purpose, passive avoidance and Y-maze tests were performed to evaluate the potential effect ‎of DAG-EO in the attenuation of memory impairment induced by 49 days administration of D-‎galactose and acute injection of scopolam...