OBJECTIVE The authors sought to identify patterns and associations of prescription and over-the-counter sedative-hypnotic use in an older, rural, blue-collar, community-based cohort in southwestern Pennsylvania over 10 years. METHODS A group of 1,627 individuals age 65 and over were recruited and assessed during 1987-1989 and re-assessed during approximately biennial waves. Data included slee...

BACKGROUND/AIMS Sedative use is common in endoscopic examinations. The anxiety regarding sedative use may be different between doctors and nonmedical individuals. METHODS A questionnaire survey was conducted by a research company (DOOIT Survey), and responses were collected from 649 doctors and 1,738 individuals who perform typical jobs in nonmedical fields. In this study, these ordinary work...

In Iranian traditional medicine, plants belonging to Inula genus have been used for the treatment of seizure. We decided to investigate the anticonvulsant activity of seven species from this genus to find an effective remedy for seizure with less adverse effects compared to available medicines. Aqueous and methanolic extracts of Inula britannica, Inula helenium, Inula viscidula, Inula oculus-ch...

Studies prove that using aromatherapy with lavender oil generates reduction of anxiety, sedative, antidepressant, soothing, antispasmodic, analgesic and healing effects. A fact occurs due to the inhibitory action on hypothalamic-hypophysis-adrenal axis, which results in release cortisol, stress hormone. Promoting, other hand, serotonin, generating a feeling pleasure well-being. Thus, present st...

To ensure that sedative agents in the intensive care unit are used for maximum benefit, a guideline that promotes the accurate and continuous assessment of patients' needs is indicated. This observational 24-month prospective study investigated the effect of introducing a sedation management guideline into a 10-bedded multidisciplinary intensive care unit on length of stay, severity of illness,...

This study examined the effects of stimulating and sedative music on ratings of perceived exertion (RPE), heart rate (HR), blood pressure (BP), and feeling status during exercise in cardiac rehabilitation (CR) patients. Twenty-two male and female older adults age 64 ± 8.0 y currently enrolled in phase III CR completed the study. Repeated measures crossover designs guided data collection. The ma...

Asperugo procumbens L. has been used in Iranian traditional medicine for the refreshing, tranquillizing and mood elevating activities. The present study was undertaken to evaluate the antidepressant and sedative-hypnotic potential of acute administration of the hydroalcoholic extract of this plant in mice. Additionally, the effects of flumazenil on the hypnotic activity of the extracts were eva...

In search of bioactive molecules in the class of functionally substituted heterocyclic compounds, we synthesized some new N-(1-methyl-1H-pyrazole-4-carbonyl)thiourea derivatives and evaluated their analgesic and sedative effects. The obtained compounds were characterized by elemental analysis, IR and NMR spectroscopic analyses and evaluated for their analgesic and sedative effects.

objective: the present study was undertaken to evaluate the possible analgesic, neuropharmacological, anti-diarrheal, and cytotoxic activities of the ethanol extract of leaves of solanum sisymbriifolium lam. (family: solanaceae). materials and methods: the analgesic activity was measured by acetic acid-induced writhing inhibition test. the neuropharmacological activities were evaluated using ho...

Asperugo procumbens L. has been used in Iranian traditional medicine for the refreshing, tranquillizing and mood elevating activities. The present study was undertaken to evaluate the antidepressant and sedative-hypnotic potential of acute administration of the hydroalcoholic extract of this plant in mice. Additionally, the effects of flumazenil on the hypnotic activity of the extracts were eva...