One of the most characteristic features of habitual behaviors is that they can be evoked by a single cue. In the experiments reported here, we tested for the effects of such advance cueing on the firing patterns of striatal neurons in the sensorimotor striatum. Rats ran in a T-maze with instruction cues about the location of reward given at the start of the runs. This advance cueing about rewar...

OBJECTIVES Maternal infection during pregnancy increases risk of severe neuropsychiatric disorders, including schizophrenia and autism, in the offspring. The most consistent brain structural abnormality in patients with schizophrenia is enlarged lateral ventricles. However, it is unknown whether the aetiology of ventriculomegaly in schizophrenia involves prenatal infectious processes. The prese...

The Battery for the Assessment of Auditory Sensorimotor and Timing Abilities (BAASTA) is a new tool for the systematic assessment of perceptual and sensorimotor timing skills. It spans a broad range of timing skills aimed at differentiating individual timing profiles. BAASTA consists of sensitive time perception and production tasks. Perceptual tasks include duration discrimination, anisochrony...

AbstractBackground Exposure to maternal immune activation (MIA) in utero is a risk factor for neurodevelopmental disorders later life. The impact of the gestational timing MIA exposure on downstream development remains unclear. Methods We characterized trajectories mice exposed viral mimetic poly I:C (polyinosinic:polycytidylic acid) either day 9 (early) or 17 (late) ...

1 A closed-loop approach to sensorimotor behaviors.................................p.9 1.1. Defining sensorimotor behaviors 1.1.1. Eliciting sensory input 1.1.2. Measuring motor output 1.2. Modulating sensorimotor behaviors 1.2.1. Sensory feedback 1.2.2. Neuromodulation 1.3. Modeling sensorimotor behaviors 1.3.1. Behavioral computations 1.3.2. Circuits computations 2 An open-loop access: sensor...

Abstract Objective: Chiari 1 malformation (CM1) occurs when the cerebellum bulges through an opening at base of skull, putting pressure on brain and spinal cord. CM1 is frequently related to syringomyelia, characterized by a fluid filled cyst in associated with sensorimotor symptoms such as headache, weakness arms, difficulty walking. This case study will expand upon existing literature regardi...

Developmental coordination disorders (DCD) affect approximately 6% of school aged children and significantly impair their activities of daily living and their academic performance. These impairments are not explicable by age, IQ or neurological condition.1,2 Some studies suggest that deficits in motor coordination among children with DCD could be related to sensory processing difficulties (SPD)...

OBJECTIVE To study planning of movement in Parkinson's disease. METHODS The spatiotemporal pattern of movement related desynchronisation (MRD) preceding a self paced voluntary wrist flexion was compared between two groups of 10 untreated right and left hemiparkinsonian patients receiving no treatment and 10 control subjects. The MRD was computed in the 9 to 11 Hz frequency band from 11 source...