This study was designated to evaluate the influence of behavioral depression on the airway leukocyte recruitment in allergic animals. To achieve this, total and differential cell counts in bronchoalveolar (BAL) fluid of ovalbumin (OVA)-sensitized and depressed rats was evaluated. Inescapable electric footshock, applied on day 0, 7 and 13 after OVA sensitization, was used as a model to induce de...

phosphodiesterases  (pde)  hydrolyse intracellular camp  and  cgmp  to  inactive  5’ monophosphates. decreased level of camp is involved in the pathogenesis of asthma. we and others have shown that phosphodiesterases were upregulated in the lung of allergic rats, and bacilli calmette-guérin (bcg) induced the production of camp in vitro. however, it is unclear how bcg’s effect asthma and whether...

Abstract Objective This study was aimed at determining the nephroprotective potential of Sphaeranthus indicus Linn methanol extract (SME) against hyperglycemia and dyslipidemia in streptozotocin (STZ)-induced diabetic nephropathy (DNP) adult Wistar albino rats. Materials Methods Following STZ-induced diabetes, rats either sex with serum glucose level more than 250 mg/dL were chosen randomized i...

BACKGROUND Fluctuations of estradiol and progesterone levels caused by the menstrual cycle worsen asthma symptoms. Conflicting data are reported in literature regarding pro and anti-inflammatory properties of estradiol and progesterone. METHODS Female Wistar rats were ovalbumin (OVA) sensitized 1 day after resection of the ovaries (OVx). Control group consisted of sensitized-rats with intact ...

We reported previously that no classical features of hyperacute rejection (HAR) could be found in liver grafts in the guinea-pig (GP)-to-rat model and that recipients died shortly after transplantation of non-immunologic causes. Thus, the GP-to-rat model is not suitable for studying the mechanisms of discordant liver xenograft rejection. In the hamster to rat model, long-term survival of a live...

Objective: To investigate the role of IL-12 in the pathogenesis of Otitis media with effusion (OME) in animal model induced by ovalbumin. Methods: Twenty-four Sprague-Dawley (SD) rats were randomly divided into three group as OME group, IL-12 group, and control group. The rats of OME group were sensitized to OVA via intraperitoneal injection once a week for two weeks and then challenged transty...