Abstract In recent years, the importance of nanomaterials in food science, medicine, etc. has been increasing quickly. Herein, organic and inorganic red selenium nanoparticles synthesised by reduction sodium selenite with chemical biological reducing agents. Grey hexagonal form aqueous powder was assembled at a high temperature 85 °C for 10 min. Also, enriched yogurt made that contained about 2...

Recently, rapid advancement in nanomedicine has opened new horizons towards the treatment of disparate types cancer. Nanomedicine is considered as science applying nanoparticles (NPs) for various diagnostic or therapeutic aims. Nanoparticles have attracted increasing interest all over world cancer due to their noteworthy properties such negligible toxicity and great bioactivity. The main object...

Selenium nanoparticles (SeNPs) with a bright red colour have aroused worldwide attention due to their unique properties in selenium supplementation because of low toxicity and favourable bioavailability. A simple method was developed for making nanolayer on the inner surface Polyvinyl chloride (PVC) silicone tube. The were produced by reaction sodium selenite ascorbic acid. Red amorphous been s...

Abstract Propolis is a natural bee product with phenolic components and flavonoid content. As propolis hydrophobic, it poorly absorbed by the body, querying use of other technologies. This review focuses on biosynthesis, characterization, evaluation some biological activities nanoparticles (AgNPs SeNPs). The were generated utilizing extract, taking into account benefits green nanoparticle synth...

Post-translational modification by bonding of small ubiquitin-like modifier (SUMO) peptides influences various cellular functions, and is regulated by SUMO-specific proteases (SENPs). Several proteins have been suggested to have diverse impact on insulin synthesis and secretion through SUMO modification in β cells. However, the role of SUMO modification in β cell mass has not been established. ...

The modification of proteins with SUMO (small ubiquitin-related modifier) plays an important role in determining their functional properties. Importantly though, SUMOylation is a highly dynamic process enabling transient responses to be elicited. This dynamism is controlled by two competing conjugating and deconjugating activities. The latter activity is mediated by the SENP [SUMO1/sentrin/SMT3...

The association of small, ubiquitin-related modifier-specific isopeptidases (also known as sentrin-specific proteases, or SENPs) with nuclear pore complexes (NPCs) is conserved in eukaryotic organisms ranging from yeast to mammals. However, the functional significance of this association remains poorly understood, particularly in mammalian cells. In this study, we have characterized the molecul...

SUMOylation is a dynamic and reversible process. Several SUMO-specific proteases (SENPs) that remove SUMO from substrates have been shown to be amplified in a subset of cancers. SENP5 is required for cell division, as well as maintaining mitochondrial morphology and function. SENP5 has been reported to be predominantly localized to the cytoplasm of oral squamous cell carcinoma (OSCC) and is ass...

Förster resonance energy transfer (FRET) technology has been widely used in biological and biomedical research. This powerful tool can elucidate protein interactions in either a dynamic or steady state. We recently developed a series of FRET-based technologies to determine protein interaction dissociation constant and for use in high-throughput screening assays of SUMOylation. SUMO (small ubiqu...

Posttranslational modification by the small ubiquitin-like modifier (SUMO) peptides, known as SUMOylation, is reversed by the sentrin/SUMO-specific proteases (SENPs). While increased SUMOylation reduces β-cell exocytosis, insulin secretion, and responsiveness to GLP-1, the impact of SUMOylation on islet cell survival is unknown. Mouse islets, INS-1 832/13 cells, or human islets were transduced ...