Seminal plasma is complex fluid containing a wide variety of both organic and inorganic components, among which proteins are an important part of the high-molecular-weight substances. The protein composition of mammalian seminal plasma varies in species and has important effect on sperm functions such as sperm motility (Henricks et al., 1998), viability (Brandon et al., 1999) and freezability (...

Introduction: Leptin is a critical metabolic signal linking nutrition and reproductive functions. Leptin receptors are expressed in germ cells, Sertoli and Leydig cells. Oxidative stress increases sperm DNA damages. Nitric oxide is a free radical, produced by most cells via Nitric Oxide (NO) synthase and plays stimulatory and inhibitory roles on cells. Physiological concentrations of NO are ess...

Seminal plasma is a promising biological fluid to use for noninvasive clinical diagnostics of male reproductive system disorders. To verify a list of prospective male infertility biomarkers, we developed a multiplex selected reaction monitoring assay and measured the relative abundance of 31 proteins in 30 seminal plasma samples from normal, nonobstructive azoospermia and post-vasectomy individ...

BACKGROUND Seminal plasma serves as a natural reservoir of antioxidants. It helps to remove excessive formation of reactive oxygen species (ROS) and consequently, reduce oxidative stress. Proteomic profiling of seminal plasma proteins is important to understand the molecular mechanisms underlying oxidative stress and sperm dysfunction in infertile men. METHODS This prospective study consisted...

The human seminal plasma protein PSP94 is a small protein of 94 residues that contains ten cysteines. Since its discovery about 25 years ago, several potential biological functions have been reported for this protein. Many PSP94 homologues have also been identified since then from various species, but no crystal structure has been determined to date. PSP94 has been purified from human seminal p...

Mammalian seminal plasma contains many distinct components which are important for spermatozoal function and survival. Recent studies clearly indicated that gossypol has pronounced hazardous effects on seminal characteristics and seminal plasma constituents in male rabbits, which may lead to deleterious productive and reproductive performance. We examined the possible deleterious effects of two...

Human seminal plasma contains a large array of proteins of clinical importance which are essentially needed to maintain the reproductive physiology of spermatozoa and for successful fertilization. Thus, isolation and identification of seminal plasma proteins is of paramount significance for their biophysical characterization and functional analysis in reproductive physiological processes. In th...

The present research was undertaken to determine the role of seminal plasma in heat stress (HS) infertility. Males were exposed to HS at 32 C or maintained at 21 C as controls. Centrifugation and reconstitution of semen samples created four final treatments: control sperm + control plasma (CsCp), control sperm + HS plasma (CsHp), HS sperm + HS plasma (HsHp), and HS sperm + control plasma (HsCp)...