Plasmodium falciparum plasmepsin-I (PM-I) has been considered a potential drug target for the parasite that causes fatal malaria in human. Determination of PM-I structures for rational design of its inhibitors is hindered by the difficulty in obtaining large quantity of soluble enzyme. Nearly all attempts for its heterologous expression in Escherichia coli result in the production of insoluble ...

Experimental Determination of Thermodynamic and Kinetic Properties of Semi-volatile Organic Aerosols by Rawad Saleh Department of Civil and Environmental Engineering Duke University Date:_______________________ Approved: ___________________________ Andrey Khlystov, Supervisor ___________________________ Ana Barros ___________________________ Prakash Bhave ___________________________ Claudia Gun...

We establish a Lipschitz stability estimate for the inverse problem consisting in the determination of the coe cient σ(t), appearing in a Dirichlet initial-boundary value problem for the parabolic equation ∂tu − ∆xu + σ(t)f(x)u = 0, from Neumann boundary data. We extend this result to the same inverse problem when the previous linear parabolic equation is changed to the semi-linear parabolic eq...

In this paper we address the problem of approximating functions on a semi-in nite interval by truncated series of orthonormal generalized Laguerre functions. The generalized Laguerre functions contain two parameters, namely a scale factor and an order of generalization. The rate of convergence of a generalized Laguerre series depends on the choice of these parameters. Results concerning the det...

Maximising the yield of the second order reaction (2-butanol + propionic anhydride) by manipulating the inlet flow rate is considered for an isothermal semi-batch process. First a procedure for the determination of the kinetic parameters using coupled spectroscopic and calorimetric methods is presented. Then an optimisation of the considered reaction is performed numerically and verified experi...

We describe a fast, accurate method for determination of the optical coefficients of 'semi-infinite' and 'infinite' turbid media. For the particular case of time-resolved reflectance from a biological medium, we show that a single Monte Carlo simulation can be used to fit the data and to derive the absorption and reduced scattering coefficients. Tests with independent Monte Carlo simulations sh...

The determination of quark angular momentum requires the knowledge of the generalized parton distribution E in the forward limit. We assume a connection between this function and the Sivers transverse-momentum distribution, based on model calculations and theoretical considerations. Using this assumption, we show that it is possible to fit nucleon magnetic moments and semi-inclusive single-spin...

We describe the design and production of a tobacco mosiac virus mutant that provides for specific and stoichiometric attachment of a wide variety of ligand-linker groups. As a result, specific ligands could be chemoselectively linked to the virion to produce highly diverse nanomolecular materials. These included semi-crystalline protein arrays and metallic ‘nanopipes’, as well as nanomolecular ...

Automated X-ray data recording and reduction strategies are straightforward powerful these days, as well semi-automated routines to solve standard structures without, or at least with only little manual intervention within a relatively short time. The structure determination of the amino-carborane closo -9-[4-(dibenzylamino)phenyl]-1,2-dicarbadodecaborane(12), C 22 H 29 B 10 N, is an example th...