The recently completed Selenium and Vitamin E Cancer Prevention Trial (SELECT) was one of the largest human cancer prevention trials ever undertaken. Its purpose was to assess the role of selenium and vitamin E in prostate cancer prevention, but SELECT found no decline in prostate cancer. Comparison of this study to other clinical trials involving selenium and to the results of animal studies s...

The blood selenium (Se) concentration in the U.K. population has declined by approx. 50% between 1974 and 1991, reflecting a large decrease in dietary Se supply, with intakes only half the reference nutrient intake of 1 microg/kg body weight. Tissue levels of Se are readily influenced by dietary intake. Therefore selenoprotein activity may be sub-optimal due to low Se status, and thus compromis...

Selenium is an essential element known to take part in human antioxidative defense and to protect against cardiovascular diseases and cancer. Consequently, supplementation of the diet with this element is necessary in order to achieve the protective effect. Several allium plants, radish etc have demonstrated the ability to preconcentrate and biotransform inorganic selenium into selenoaminoacids...

Povzetek. Sodobne organizacije se spreminjajo zelo pogosto. Spremembe se poskuša izvesti hitro in učinkovito. Spremembe pogosto vključujejo spremembe IS zaradi njegovega pomena v organizacijah. Odpor do sprememb spada med ključne dejavnike uspeha večjih projektov in programov IT. Obvladovanje odpora ne pomaga organizacijam zgolj izvesti spremembe hitreje in učinkoviteje, temveč je hkrati tudi p...

The crystal structure of gpD, the capsid-stabilizing protein of bacteriophage lambda, was solved by multiwavelength anomalous diffraction (MAD) for a selenomethionine (SeMet) derivative of the protein at 1.8 A resolution, using crystals in space group P2(1) [Yang et al. (2000), Nature Struct. Biol. 7, 230-237]. Subsequent analysis showed that the crystals of both the original protein and the Se...

Selenium, an element long known to be toxic to living organisms (1, 2), has only recently been implicated as an essential trace element for rats (3), chicks (4,5) and several other animals. The work of Franke (6), Horn et cd. (7), Painter (8, 9), and McConnell (10, 11) established that if toxic amounts of selenium were supplied in various chemical forms to a number of plants, animals, and micro...