Changes in thyroid function may affect mood, behavior, and cognitive function. Selenium is required for appropriate thyroid hormone synthesis, activation, and metabolism. Selenium status influences thyroid function. Selenium status also affects psychological condition and cognitive function. The author suggests that the effects of selenium status on mood, behavior, and cognition may be partly m...

Selenium, an antioxidant enzyme component, has been shown to protect against colorectal cancer risk. A diet is the primary source of these antioxidants, and selenium level inversely related risk may be responsible for around 50% The study aims evaluate levels as a marker participants in this were 180 individuals, comprising patients healthy people, separated into two distinct groups: first comp...

Protein fractions from three selenium-tolerant and three selenium-sensitive Astragalus species, grown in the presence of [(75)Se]selenate, were analyzed for their selenium content. Though tolerant species are known to accumulate considerably more selenium than do sensitive plants, protein fractions from the three selenium accumulators were found to contain significantly less selenium (0.46 to 0...

Selenoprotein P (Se-P) contains most of the selenium in plasma. Its function is not known. Mice with the Se-P gene deleted (Sepp(-/-)) were generated. Two phenotypes were observed: 1) Sepp(-/-) mice lost weight and developed poor motor coordination when fed diets with selenium below 0.1 mg/kg, and 2) male Sepp(-/-) mice had sharply reduced fertility. Weanling male Sepp(+/+), Sepp(+/-), and Sepp...

The brain and testis retain selenium better than other tissues during selenium deficiency. Studies of mice with selenoprotein P (Sepp1) deleted (Sepp1(-/-) mice) showed that brain and testis selenium levels are largely dependent on Sepp1. Therefore, we examined tissue selenium in mice fed varying amounts of selenium and in Sepp1(-/-) mice to characterize better the role(s) of Sepp1. Mice were f...

BACKGROUND & AIMS Plasma selenium concentration and glutathione peroxidase (GPx) activity are commonly used as markers of selenium nutritional status. However, plasma selenium concentrations fall independently of selenium status during the acute phase response and GPx is analytically problematic. The assay for erythrocyte selenium is robust and concentrations are unaffected by the systemic infl...

Selenium-containing proteins (e.g., glutathione peroxidases) are important antioxidants in neuronal defense against oxidative stress. In this study, the production of amyloid-β (Aβ) plaques in the brain of the Tg2576 transgenic mice was investigated under dietary selenium-deficient conditions. The 16-week-old mice were fed a selenium-deficient diet (0.004 μg-selenium g(-1)-diet) or a selenium-a...

Introduction Research efforts have identified groups of people with low selenium intakes and presumed selenium deficiency based on low blood selenium levels. Inhabitants of New Zealand [1], Finland [2], and China [3] often have low blood selenium. Individuals with therapeutic diets low in selenium [4], people undergoing parenteral administration [5] and alcoholics with cirrhosis [6] can also be...

Selenium (Se) is an essential element for human health in trace amounts but harmful excess. Most plants contain a fairly low Se and crop supplements ensure adequate levels nutritional needs. Food the primary source of humans due to differences eating habits, its intake varies considerably. In body, selenium deficiency can lead diseases endocrine, musculoskeletal, cardiovascular, reproductive, n...