Differently substituted β-hydroxy- and β-amino dialkyl alkyl-aryl tellurides selenides have been prepared through ring-opening reactions of epoxides aziridines with selenium- or tellurium-centered nucleophiles. The antioxidant properties the cytotoxicity such compounds investigated on normal human dermal fibroblasts. Most studied exhibited a low number them proved to be non-toxic, not showing a...

Peroxynitrite (ONOO-/ONOOH) is a powerful oxidant that can induce mutations and cause single-strand breaks in plasmid supercoiled DNA. The selenium-containing compound ebselen rapidly reacts with peroxynitrite. Therefore, ebselen [2-phenyl-1,2-benzisoselenazol-3(2H)-one] and other selenium-containing molecules, selenomethionine and selenocystine, were studied as agents protecting DNA from singl...

PURPOSE Studies were carried out in athymic nude mice bearing human squamous cell carcinoma of the head and neck (FaDu and A253) and colon carcinoma (HCT-8 and HT-29) xenografts to evaluate the potential role of selenium-containing compounds as selective modulators of the toxicity and antitumor activity of selected anticancer drugs with particular emphasis on irinotecan, a topoisomerase I poiso...

Selenium poisoning in humans is reviewed from the perspective of the clinical laboratory. While evaluation of selenium poisoning is straightforward when the analytic results are markedly elevated and the patient is acutely symptomatic, distinguishing toxic from non-toxic elevations is a more frequent issue and more challenging. A significant problem is that selenium is determined as its total c...

The essential trace element selenium has long been considered to exhibit anti-diabetic and insulin-mimetic properties, but recent epidemiological studies indicated supranutritional selenium intake and high plasma selenium levels as possible risk factors for development of type 2 diabetes, pointing to adverse effects of selenium on carbohydrate metabolism in humans. However, increased plasma sel...

The chemistry of the chalcogen azides has been well investigated in the last years [1]. Among the various possible oxidation states of the chalcogens, selenium(IV) and tellurium(IV) possess the highest stability, and the ionic chalcogen(IV) azides [R3Te]N3 and [R3Se]N3 have been described and thoroughly characterized recently [2, 3]. In addition, the first telluronium, selenonium and sulfonium ...

The world's rare selenium resources need to be managed carefully. Selenium is extracted as a by-product of copper mining and there are no deposits that can be mined for selenium alone. Selenium has unique properties as a semi-conductor, making it of special value to industry, but it is also an essential nutrient for humans and animals and may promote plant growth and quality. Selenium deficienc...

Organoselenium compounds have recently been the experimentalists' delight due to their broad applications in organic synthesis, medicinal chemistry, and material sciences. Selenium atom replacement of carbonyl oxygen the...

Selenium, an element long known to be toxic to living organisms (1, 2), has only recently been implicated as an essential trace element for rats (3), chicks (4,5) and several other animals. The work of Franke (6), Horn et cd. (7), Painter (8, 9), and McConnell (10, 11) established that if toxic amounts of selenium were supplied in various chemical forms to a number of plants, animals, and micro...