Three 1-methoxy analogs of CP-47,497 (7, 8, and 19) have been synthesized and their affinities for the cannabinoid CB(1) and CB(2) receptors have been determined. Although these compounds exhibit selectivity for the CB(2) receptor none have significant affinity for either receptor. Modeling and receptor docking studies were carried out, which provide a rationalization for the weak affinities of...

This letter proposes a novel decoding scheme for Alamouti’s space–time (ST) coded transmissions over time-selective fading channels that arise due to Doppler shifts and carrier frequency offsets. Modeling the time-selective channels as random processes, we employ Kalman filtering for channel tracking in order to enable ST decoding with diversity gains. Computer simulations confirm that the prop...

S ri e o l a re n d o i i z S a t n u r e d t i n A I v a a l n o z u a c t S i-m a a z p n e e r c s s o eg n u o i c r e v i e rtut Modeling the catalyst selectivity in the ethylene epoxidation reaction A first principles study Thesis submitted for the degree of

In an attempt to identify potential new agents that are active against HIV-1, a series of novel pyridopyrimidine-5-carbohydrazide derivatives featuring a substituted benzylidene fragment were designed and synthesized based on the general pharmacophore of HIV-1 integrase inhibitors. The cytotoxicity profiles of these compounds showed no significant toxicity to human cells and they exhibited anti...

HCV-induced hepatitis is one of the most debilitating diseases. The limited number of anti-HCV drugs and drug-resistance necessitate developing of new scaffolds with different mode of actions. HCV non-structural protein 5B (NS5B) is an attractive target for development of novel inhibitors of HCV replication. In this paper, new N'-arylidene-6-(benzyloxy)-4-oxo-1,4-dihydroquinoline-3-carbohydrazi...

The light-activated microbial ion channel channelrhodopsin-2 (ChR2) is a powerful tool to study cellular processes with high spatiotemporal resolution in the emerging field of optogenetics. To customize the channel properties for optogenetic experiments, a detailed understanding of its molecular reaction mechanism is essential. Here, Glu-90, a key residue involved in the gating and selectivity ...