Background: Selective serotonin reuptake inhibitors (SSRIs) have been associated with depletion of serotonin in platelets, and risk of bleeding. Objective: The main objective is to report the cases of two young males with no medical problems other than their psychiatric disorders presenting with lower gastrointestinal bleeding after paroxetine use. Method: We report two cases of lower gastroint...

Selective serotonin reuptake inhibitors (SSRIs) are increasingly used during pregnancy and lactation, with 1.8-2.8% exposed pregnancies. Given the risks of untreated maternal depression for both mother and child, adequate treatment is essential. If pharmacological treatment with SSRIs is indicated, the fetal and neonatal effects of SSRIs have to be considered, as SSRIs cross the placenta and ar...

Steroid withdrawal syndrome (SWS) following steroid dependence is becoming a common clinical condition. It may be associated with body image disorder. Though selective serotonin reuptake inhibitors (SSRIs) are found to be effective SWS associated depression, data for this clinical condition is limited. We present a case of SWS associated with body image disorder which improved with mirtazapine....

The data provided here related to our research article (Chen et al., 2016) [1]. We provide whole-brain intrinsic functional connectivity patterns in obsessive-compulsive disorder at resting-state [1]. This article also provides supplementary information to our research article, i.e., between - group comparisons of the effect of selective serotonin reuptake inhibitors (SSRIs) and combined depres...

Objectives: The purpose of the study was to assess the relationship between selective serotonin reuptake inhibitors use and hepatocellular carcinoma in Taiwan. Methods: Using the database of the Taiwan National Health Insurance Program, we conducted a case-control study to identify 4901 subjects aged 20 years and more with newly diagnosed hepatocellular carcinoma in 2000-2013 as the cases. We r...

Among drug-induced liver injuries (DILI), the cholestatic type is second in frequency (from 20 to 40%), most common hepatocellular variant (up 78%). For this reason, practitioners of various specialties, including neurologists and psychiatrists, do not monitor cholestasis parameters, injury with (DILIС) remains unrecognized. The urgency problem great, because deaths DILIС only slightly lower th...

Binge Eating Disorder (BED) is a common atypical eating disorder. The treatment of BED calls for multi-professional expertise and co-operation between doctors, psychologists and nutritional therapists. Different therapeutic and psychosocial approaches are the primary means in treating BED. Medication may be used as supportive treatment. Selective serotonin reuptake inhibitors (SSRIs) are the mo...

P ractitioners of pediatric medicine may still be undecided as to whether the newer generation of antidepressant drugs is effective for child and adolescent depression (CAD) [1]. Since 1989, when selective serotonin reuptake inhibitors (SSRIs) were introduced in the United States, they have become the top-selling drug category; as many as one in eight adult Americans having tried at least one S...

New data on the pharmacology of tricyclic antidepressants (TCAs), their affinities for human cloned CNS receptors and their cytochrome P450 enzyme inhibition profiles, allow improved deductions concerning their effects and interactions and indicate which of the TCAs are the most useful. The relative toxicity of TCAs continues to be more precisely defined, as do TCA interactions with selective s...

Hypochondriasis is a condition characterized by an unrealistic fear of having serious medical illness resulting in health anxiety. Currently, no evidence-based pharmacological treatment options are available for the hypochondriasis. Since selective serotonin reuptake inhibitors (SSRIs) first-line option anxiety disorders, they may be useful relieving hypochondriasis symptoms. Moreover, off-labe...