The C-19 quassinoid eurycomalactone (1) has recently been shown to be a potent (IC50 = 0.5 μM) NF-κB inhibitor in a luciferase reporter model. In this study, we show that 1 with similar potency inhibited the expression of the NF-κB-dependent target genes ICAM-1, VCAM-1, and E-selectin in TNFα-activated human endothelial cells (HUVECtert) by flow cytometry experiments. Surprisingly, 1 (2 μM) did...

A chalcogenide glass capable of infrared transmission which is either sulfur, selenium or tellurium based and consists of compositions of the formula MX+M.sub.2 'X.sub.3 +SiX.sub.2, wherein M is one of the metals calcium, strontium, barium, zinc and lead, and M' is either aluminum or gallium and X is either sulfur, selenium or tellurium. Aluminum or gallium chalcogenide acts to increase the cov...

BACKGROUND Although numerous genetic studies have been performed, only 0.9% of blood pressure phenotypic variance has been elucidated. This phenomenon could be partially due to epistatic interactions. Our aim was to identify epistatic interaction(s) associated with blood pressure levels in a pre-planned two-phase approach. METHODS AND RESULTS In a discovery cohort composed of 3,600 French ind...

The NF-κB pathway is involved in immune and inflammation responses, proliferation, differentiation and cell death or survival. It is activated by many external stimuli including genotoxic stress. DNA double-strand breaks activate NF-κB in an ATM-dependent manner. In this manuscript, a direct interaction between p65(RelA) and the N-terminal extremity of ATM is reported. We also report that only ...

No presente artigo foram analisadas as mortes decorrentes de infecção do trato respiratório ou por pneumonia nos anos 2016, 2017, 2018 e 2019 nas regiões Brasil no páis. Assim, esta pesquisa tem objetivo compilar, analisar estimar a taxa morte inferior cada 100 mil habitantes, em âmbito nacional regional, disponibilizados banco dados Sistema Informações sobre Mortalidade (SIM) domínio público s...

Erzincan’da 9 Haziran 2022 tarihinde ikindi sularında başlayan dolu ile karışık şiddetli sağanak yağmur ve yamaçları örten dolunun hızla erimesiyle harekete geçen sular sele zemin hazırlamıştır. Tespitlerimize göre suları Esence Dağları’nın güney yamaçlarındaki gevşek malzemeyi yerinden oynatmış, kabaran yer iri kayaçları da önüne katarak dönüşmüştür. Sel, ekseriyetle yaz mevsiminde kuruyan Mad...