neurokinin 1 receptors (nk1r) are overexpressed on several types of important human cancer cells. substance p (sp) is the most specific endogenous ligand known for nk1rs. accordingly, a new sp analogue was synthesized and evaluated for detection of nk1r positive tumors. [6-hydrazinopyridine-3-carboxylic acid (hynic)-tyr8-met(o)11-sp] was synthesized and radiolabeled with 99mtc using ethylenedia...

The Gram-positive, soil-inhabiting, filamentous bacterial genus Streptomyces employs gamma-butyrolactones as chemical signalling molecules or microbial hormones, together with their specific receptors, to regulate morphological and/or physiological differentiation. The A-factor regulatory cascade in streptomycin-producing Streptomyces griseus commences aerial mycelium formation and production o...

The o and p bandlets of the leech embryo are parallel columns of ectodermal blast cells which are identified by their relative positions, and which during normal embryogenesis follow distinct developmental pathways. A previous study showed that o blast cells are initially capable of following either the O or P pathway, and suggested that commitment to the O pathway depends upon interaction with...

background & aim: medicinal plants are most valuable and useful sources as productive factors of drugs. production and extraction of secondary metabolites have a huge economical importance in recent years. carvone is a compound in bunium persicum fruit and shoot and, it is one of the wide range varieties of valuable and useful secondary metabolites. due to limited crop production, using app...

Background & Aim: Medicinal plants are most valuable and useful sources as productive factors of drugs. Production and extraction of secondary metabolites have a huge economical importance in recent years. Carvone is a compound in Bunium persicum fruit and shoot and, it is one of the wide range varieties of valuable and useful secondary metabolites. Due to limited crop production, usin...

Studies of costimulatory receptors belonging to the TNFR family have revealed their diverse roles in affecting different stages of the T cell response. The 4-1BB ligand (4-1BBL)/4-1BB pathway has emerged as a receptor-ligand pair that impacts not the initial priming, but later phases of the T cell response, such as sustaining clonal expansion and survival, maintaining memory CD8(+) T cells, and...

OBJECTIVE In multiple myeloma (MM), seven primary recurrent translocations involving the immunoglobulin heavy chain locus have been identified. One of the partner loci maps to 20q12 and involves the MAFB gene resulting in its ectopic expression. We attempt here to identify MAFB target genes in MM. MATERIALS AND METHODS We used an inducible system to upregulate MAFB in MM cell lines not carryi...