نتایج جستجو برای: second primary neoplasm
تعداد نتایج: 1344479 فیلتر نتایج به سال:
We report a rare case of complete remission for 32 months with continuous treatment with all-trans retinoic acid (ATRA) alone in a patient with acute promyelocytic leukemia which developed as a second malignancy after the treatment of osteosarcoma after failure of conventional chemotherapy. The adverse effects of ATRA were apparently tolerable.
Colorectal cancer is the third most frequent cancer in the Western world. About half of the patients develop synchronous or metachronous metastases. The liver is the most common site of such metastases and thus hepatic metastatic disease is a significant socio-medical problem. If it is not treated, the median patient survival is only some months. Surgical resection is the treatment of choice fo...
BACKGROUND Clinical experiences suggest that breast cancer (BC) and thyroid cancer (TC) occur metachronously or synchronously in a patient more frequently than it would by chance. This study was conducted to investigate the clinicopathological characteristics and survival of these double primary malignancies. METHODS 18732 patients with first primary BC and 12877 female patients with first pr...
Malignant melanoma is a common skin neoplasm bearing poor prognosis when presenting with metastases. Rarely melanoma metastases present without an identifiable primary cutaneous lesion despite exhaustive workup. We describe the case of a solitary lung metastasis in a patient with neurofibromatosis type 1 without an identifiable primary tumour. The rapid progression of this malignant neoplasm th...
Secondary Malignant Neoplasm(SMN) is one of the late effects of childhood cancer. Among secondary malignancies, acute myeloid leukemia(AML) is the most common and life-threatening neoplasm. Secondary acute lymphoblastic leukemia(ALL) is rare and only 10% of SMN is ALL. Patients with Wilm’s tumor are not protected from the secondary cancers after the primary diagnosis. Among patients...
BACKGROUND The etiology of secondary cancer in childhood cancer survivors is largely unclear. Exposure of normal somatic cells to radiation and/or chemotherapy can damage DNA and if not all DNA lesions are properly fixed, the mis-repair may lead to pathological consequences. It is plausible to assume that genetic differences, i.e. in the pathways responsible for cell cycle control and DNA repai...
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