The use of sex hormones as potential neurosteroids capable of enhancing neuronal repair and functional recovery is gaining some momentum in the experimental literature. Two very interesting papers are presented in this issue of Restorative Neurology and Neuroscience outlining the effects of testosterone treatment upon anatomical and functional recovery after sciatic nerve crush injuries. The ar...

BACKGROUND Nerve conduits provide a promising strategy for peripheral nerve injury repair. However, the efficiency of nerve conduits to enhance nerve regeneration and functional recovery is often inferior to that of autografts. Nerve conduits require additional factors such as cell adhesion molecules and neurotrophic factors to provide a more conducive microenvironment for nerve regeneration. ...

Objective- To studylocal effect of prostaglandin E1on sciatic nerve regeneration Design- Experimental study Animals- Sixty male healthy white Wistar rats Procedures- Sixty animals were divided into four experimental groups (n = 15), randomly: Trasnsected (TC), Sham-operation (SHAM), control (CHIT) and prostagl...

Background: The limited availability of donor sites for nerve grafting has continued to stimulate research toward finding suitable alternatives for autograft. The aim of this research was to study the effect of piezoelectric channel and collagen gel on nerve regeneration. Materials and methods: This research is an experimental study. Forty eight male rats (200-250 gr) were used. After axotomy...

BACKGROUND Severe functional and anatomical defects can be detected after the peripheral nerve injury. Pharmacological approaches are preferred rather than surgical treatment in the treatment of nerve injuries. AIMS The aim of this study is to perform histopathological, functional and bone densitometry examinations of the effects of sildenafil on nerve regeneration in a rat model of periphera...

AIM To study the therapeutic effect of three tube-guides with electrical conductivity associated to mesenchymal stem cells (MSCs) on neuro-muscular regeneration after neurotmesis. METHODS Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol (PVA), PVA-carbon nanotubes (CNTs) and MSCs, and PVA-polypyrrole (PPy). The regenerated nerves and tibialis anterior muscles were processe...

Objective(s) Motor deficit and neuron degeneration is seen after nerve transection. The aim of this study is to determine whether a poled polyvinelidene fluoride (PVDF) tube with other supportive strategies can protect the neuronal morphology and motor function after sciatic nerve transaction in rats. Materials and Methods After transection of the left sciatic nerve in 60 male Wistar rats (2...

objective(s) motor deficit and neuron degeneration is seen after nerve transection. the aim of this study is to determine whether a poled polyvinelidene fluoride (pvdf) tube with other supportive strategies can protect the neuronal morphology and motor function after sciatic nerve transaction in rats. materials and methods after transection of the left sciatic nerve in 60 male wistar rats (200-...

D Eguiluz-Ordoñez and colleagues publish their experience with 40 rats, divided into four groups of 10. All rats underwent sharp sciatic nerve transection and repair (interfascicular and epineural) followed by various lengths of follow-up. Two of the groups were euthanized at 7 weeks, with half being treated with hyperbaric oxygen twice daily for 10 days at 2.0 atmospheres (absolute) at 90 minu...