Efforts to eliminate schistosomiasis are hindered by incomplete efficacy of the only FDA-approved antischistosomal drug, praziquantel. By using postgenomic technologies, Wendt et al. and Wang deciphered function several genes required for worm survival pathogenesis, which opens way development innovative parasite-targeted therapies. Schistosomiasis — also known as bilharziasis is one most devas...

Schistosomiasis is a parasitic disease which affects millions of people around the world, particularly in Africa. In this continent, different species are able to interbreed, like Schistosoma haematobium and Schistosoma guineensis, two schistosome species infecting humans. The Republic of Benin is known to harbor S. haematobium, but its geographical situation in between Nigeria, Mali, and Burki...

In order to evaluate differentiate genetic differences among Schistosoma japonicum isolates from Dali Ancient City, Xizhou and Yongsheng County, Yunnan Province, China, mitochondrial col, cytb, nd1, nd6, and nd4l were PCR amplified and sequenced, revealing nucleotide difference(s) among these strains of 8, 1, 5, 4, and 0, respectively. Phylogenetic analysis showed that S. japonicum from the thr...

Etiologic Agent Schistosomiasis is a disease caused by parasitic worm of genus Schistosoma [1]. It belongs to phylum Platyhelminthes, class Trematoda and genus Schistosoma [2]. Most human infections are caused by the three species: S. mansoni, S. haematobium, and S. japonicum [3]. There are two more species S. intercalatum and S. mekongi known to cause Schistosomiasis [3]. The most infections c...

The association between schistosomiasis and colorectal malignancy has long been suggested in the literature, but it is not uniformly accepted. In the Far East, considerable evidence supports an etiological link between Schistosoma japonicum and colorectal cancer. However, the available data regarding the role of Schistosoma mansoni in colorectal carcinogenesis are conflicting and most often do ...

A vaccine against schistosomiasis would contribute significantly to reducing the 3-70 million disability-adjusted life years lost annually to the disease. Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice. The EC-2 loop of Schistosoma jap...

This study was planned to evaluate the effectiveness of Myrrh in children with hepatic fascioliasis and intestinal schistosomiasis through study of clinical and parasitologic cures and assessment of serum total IgE and production of IL-1, IL-4 and IL-5 by peripheral blood mononuclear cells (PBMCs) before and after Mirazid therapy. The study included 21 children with fascioliasis, 8 children wit...