Abstract 
 Introduction: Malignant neoplasms of bone originating from the supporting tissues body mesinchymal origin are heterogeneous in clinical and histological terms. In most cases, etiology these tumors is unknown. Histologically, sarcomas classified into three main types. Chondrosarcoma (31% sarcomas), osteosarcoma - tissue (also accounts for 31% Ewing sarcoma neuroectodermal (accoun...

instability of microsatellite sequences are frequently found in human tumors. In addition, minisatellite sequences, another group of highly unstable sequences, serve as sensitive markers of genetic instability. We have studied minisatellite instability in methylcholanthrene-induced mouse sarcomas. These sarcomas frequently carry the amplified c-myc gene. Seven sarcomas without the amplification...

Soft-tissue sarcomas are heterogeneous cancers that can present with tissue-specific differentiation markers. To examine the cellular basis for this histopathological variation and to identify sarcoma-relevant molecular pathways, we generated a chimeric mouse model in which sarcoma-associated genetic lesions can be introduced into discrete, muscle-resident myogenic and mesenchymal cell lineages...

Exposure to ionizing radiation is a known risk factor for cancer. However, up to now, rigorously defined scientific criteria that could establish case-by-case the radiation-induced (RI) origin of a tumour have been lacking. To identify genes that could constitute a RI signature, we compared the transcriptome of 12 sarcomas arising in the irradiation field of a primary tumour following radiother...

BACKGROUND/AIM The purpose of this study was to analyze the incidence and survival in all sarcomas based on year of diagnosis, anatomical site, grade, stage, and age of patient. MATERIALS AND METHODS The Surveillance, Epidemiology, and End Results (SEER) database was queried for the years 1975 to 2009 and included 18 registries across the United States representing 28% of the national populat...

There are two types of sarcomas with regards to the type of molecular alterations: sarcomas with relatively simple, usually specific lesions and those with complex unspecific lesions. A molecular classification for sarcomas can therefore be proposed (Table 1). Recurrent chromosomal translocations: about 10-15% of all sarcomas bear a recurrent chromosomal translocation (Table 2). The most freque...

Ceruloplasmin (CPN) concentrations were measured by p-phenylenediamine oxidase assay in serums from (a) 30 control Fischer rats; (b) 5 rats with primary sarcomas induced by i.m. injection of nickel subsulfide (alpha Ni3S2), and (c) 12 rats at intervals up to six weeks after s.c. transplantation of four alpha Ni3S2-induced sarcomas. Serum CPN concentrations were not significantly increased in ra...