Dysferlin plays an important role in repairing membrane damage elicited by laser irradiation, and dysferlin deficiency causes muscular dystrophy and associated cardiomyopathy. Proteins such as perforin, complement component C9, and bacteria-derived cytolysins, as well as the natural detergent saponin, can form large pores on the cell membrane via complexation with cholesterol. However, it is no...

To separate the saponin rich fraction of Trigonella foenum graecum (TFG) seeds and to evaluate its influence on blood pressure in normal and hypertensive rats. The ethanolic extract of TFG seeds was fractionated with cold diethyl ether to obtain saponin rich fraction. Albino rats of Wistar strain of either sex weighing between 200 to 250 g were used for the hypertension models. Hypertension was...

The main saponin (1) present in the mesocarp of Balanites aegyptiaca fruit is a mixture of 22R and 22S epimers of 26-(O-beta-D-glucopyranosyl)-3-beta-[4-O-(beta-D-glucopyranosyl)-2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyloxy]-22,26-dihydroxyfurost-5-ene. This structure differs from a previously reported saponin isolated from this source by the site of attachment of the rhamnosyl residu...

A new oleanane-type saponin oleiferasaponin C6 (OSC6) was isolated and identified from Camellia oleifera seeds through NMR, HR-ESI-MS, and GC-MS spectroscopic methods. This new oleanane-type saponin exhibits potent cytotoxic activities on five human cancer cell lines (BEL-7402, BGC-823, MCF-7, HL-60 and KB), especially in HL-60 and BEL-7402 cell lines. The action mechanism of the anti-cancer ac...

A new steroidal saponin, 3-{(O-6-deoxy-a-L-mannopyranosyl-(1 --> 4)-O-beta-D-glucopyranosyl-(1 --> 3)-O-[O-beta-D-glucopyranosyl-(1 --> 3)-beta-D-glucopyranosyl-(1 --> 2)]-O-beta-D-glucopyranosyl-(1 --> 4)-beta-D-galactopyranosyl)oxy}-6-hydroxy-(3beta,5alpha,6alpha,25R)-spirostan-12-one, was isolated from Agave brittoniana Trel. The structure was determined by extensive NMR spectroscopy studies...

Saponins are glycosylated plant secondary metabolites found in many major food crops [Price, K. R., Johnson, I. T. & Fenwick, G. R. (1987) CRC Crit. Rev. Food Sci. Nutr. 26, 27-133]. Because many saponins have potent antifungal properties and are present in healthy plants in high concentrations, these molecules may act as preformed chemical barriers to fungal attack. The isolation of plant muta...

The author studied the hematopoietic disturbances of rabbit induced by saponin injection and drew the following conclusions: 1) By saponin injection, the structure of bone marrow is disintegrated and hematopoietic cells are released into the circulating blood forming extramedullary hematopietic foci mainly in liver and spleen. The main attacking point of saponin should be RES. Recovery of hemat...

Phytochemical investigations of Gleditsia fruits have revealed the presence of triterpenoidal saponins. These saponins proved to possess anti-inflammatory and anti-allergic activities. The present study was undertaken to evaluate the anti-inflammatory, analgesic and antipyretic activities of the saponin fraction derived from the methanolic extract of Gleditsia caspica fruits. The fraction at 31...

BACKGROUND The basophil activation test (BAT), in which translocation of markers to the surface of blood basophils is measured in response to allergen by flow cytometry, is a rapid assay that is gaining popularity. Two markers are currently being evaluated for the BAT; CD63 and the lineage-specific CD203c. In a recent report, detection of CD203c after lysis with Saponin was shown to be superior...