Plants have been the source of several effective drugs for the treatment of cancer and over 60% of anticancer drugs originate from natural sources. Therefore, extracts of the rhizome of Smilax spinosa, an ethnomedicinal plant from Guatemala which is used for the treatment of inflammatory conditions, were investigated regarding their anti-neoplastic activities. By using several solvents the meth...

Methanolic extracts of eight Salvia species, namely S. aethiopis, S. candidissima, S. limbata, S. microstegia, S. nemorosa, S. pachystachys, S. verticillata, and S. virgata, sampled from Eastern Anatolia in Turkey, were screened for their possible antioxidant activities by two complementary test systems, namely DPPH free radical scavenging and beta-carotene/linoleic acid. Total phenolic content...

The purpose of this study was to investigate the effect of Salvia miltiorrhiza on the production of plasminogen activator inhibitor-1(PAI-1) induced by angiotensin II (Ang II) in renal mesangial cells. Rat mesangial cells were exposed to 100 nM Ang II. Meanwhile, different concentrations of Salvia miltiorrhiza injection were added to Mesangial Cells. PAI-1 mRNA was measured by semi-quantificati...

The taxonomical relationship between Salvia pratensis and S. bertolonii has been unclear for a long time. Salvia bertolonii has alternatively been considered a synonym, a subspecies, a problematic subspecies and a form of Salvia pratensis. However, both these two species are sometimes used in traditional medicine instead of sage (Salvia officinalis) or as an adulteration for the same drug. In o...

Background Salvia officinalisL. has been used since ancient times but there are little data about effects of this herb on normal reproductive cells. Objective To investigate the toxicity effects of Salvia officinalis L. on granulosa cells (GCs) and maturation of oocytes. Materials and Methods GCs and oocytes were extracted from superovulated ovaries of immature mice. The cells were treated ...

BACKGROUND/AIM To evaluate acetylcholinesterase (AChE) inhibitory activity and antioxidant capacity of the major molecule from Salvia sp., rosmarinic acid, as a drug candidate molecule for treatment of Alzheimer disease (AD). MATERIALS AND METHODS The AChE inhibitory activity of different extracts from Salvia trichoclada, Salvia verticillata, and Salvia fruticosa was determined by the Ellman ...

pycnocycla spinosa decne. ex boiss. var. spinosa (fam. umbelliferae) is an essential oil-containing wild plant growing in central part of iran. hydroalcoholic extract of pycnocycla spinosa has antispasmodic and antidiarrheal activity. the aim of this study was to further investigate antidiarrheal and small intestinal transit effect of p. spinosa extract for a comparison with loperamide and dicy...

Objectives: The purpose of this work was development, formulation and testing of new herbal ointment for the treatment of mild to severe atopic dermatitis in infants and children (4 to 56 months old) as possible alternative therapy to standard corticosteroids and immunomodulants. Patients and methods: 50 patients were treated 8 weeks (every four hours) with the ointment containing the following...

OBJECTIVE To determine whether purified herbal extract of Salvia miltiorrhiza can improve the amniotic fluid volume in pre-term oligohydramnios by improving uteroplacental circulation. METHODS Forty-three pregnant women with oligohydramnios received a daily intravenous dose of 30 mL of salvia extract mixed with 5% glucose 500 mL. A control group of 41 women received daily 5% glucose 500 mL on...