Adenocarcinoma of the salivary gland is a histology subtype of salivary gland carcinoma (SGC). Salivary gland carcinomas are rare tumors accounting for less than 5% of all cancers of the head and neck. Consequently, clinical data for systemic treatment including targeted treatment in metastatic SGC is limited and supported mainly by sporadic cases, retrospective reports, and early phase trials ...

This study was carried out to study the histopathological spectrum of salivary gland tumors and to know their pattern of distribution. A combination study was done with retrospective data of eight years from june 2001 to may 2009 and prospective data of two years from June 2009 to June 2011 in the department of pathology of our hospital. The study was duly approved by Hospital Ethical Committee...

Salivary duct carcinoma (SDC) is a high-grade adenocarcinoma arising from the ductal epithelium of salivary glands which rarely involves the minor salivary glands. The varied histological presentation in the minor salivary gland tumors makes them the most heterogeneous group of neoplasms, making the diagnosis a challenge. This report highlights the importance of immunohistochemical markers in t...

The aim of this study was to investigate the radioprotective effect of thymol as a natural product against salivary glands dysfunction induced by ionizing radiation in rats. The rats were treated with thymol at dose of 50 mg/Kg before exposure to radiation at dose 15Gy. Salivary gland function was evaluated with radioisotope scintigraphy and then salivary gland to background counts ratio was ca...

Adenoid cystic carcinoma is a malignant salivary tumor that may arise in either major or minor salivary glands. Because of its frequent microscopic appearance resembling cross-sections of tubular structures (cylinders), it was previously referred to as “cylindroma.”. Clinically, adenoid cystic carcinoma is most common in the parotid gland, palate being the most common intraoral site.

OBJECTIVE To examine the therapeutic effects of an attenuated, replication-competent vaccinia virus (GLV-1h68) against a panel of 5 human salivary gland carcinoma cell lines. DESIGN The susceptibility of 5 salivary gland carcinoma cell lines to infection and oncolysis by GLV-1h68 was assessed in vitro and in vivo. RESULTS All 5 cell lines were susceptible to viral infection, transgene expre...

PURPOSE The purpose of this study was to evaluate the biological mechanisms of docetaxel (TXT) on salivary gland carcinoma. EXPERIMENTAL DESIGN The effects of TXT on a spontaneous murine salivary carcinoma were determined. Proliferation, cell cycle regulation, connexin43 expression, gap-junctional intercellular communication, apoptosis, and Fas receptor (FasR) expression were measured. RESU...

OBJECTIVE Cathepsin D is a lysosomal acid protease secreted in increased levels in several malignancies. However, its role in salivary gland tumors has not been studied extensively. The present study aims to assess the expression of Cathepsin D in malignant salivary gland tumors and to compare its expression in these tumors. STUDY DESIGN A total of 30 cases of malignant salivary gland carcino...

twenty five cases of minor saliva ry glands tumors which was observedat the department of pathology of university of tehran from 1967 to 1972 are presented and discussed . benign mixed tumor is the most common and the only benign lesion in this series of 75 patient with intraoral salivary gland tumor. there were eleven malignant type and hence about 44% of all the tumor arc malignant and it cor...