OBJECTIVES Pleomorphic adenomas are the most frequent type of epithelial salivary gland neoplasms, and their malignant counterpart, the carcinoma in pleomorphic adenomas, is much less common. Beta-catenin is a cell adhesion molecule associated with the invasion and metastasis of carcinomas of the head and neck, esophagus. The objective of this study was to detect the expression of beta-catenin ...

Immunohistochemical staining, with a monoclonal antibody specific for cytokeratins 5, 6, 8, 17 and 19 of dog submandibular, sublingual, parotid, palatine, tongue and zygomatic salivary glands resulted in staining of myoepithelial cells, duct epithelial cells (including intercalated, striated and secretory ducts) and some acinar epithelial cells. Differences in acinar staining between glands ref...

Cbfa1 (core binding factor alpha 1) is a transcription factor that is a key determinant of the osteoblastic lineage. Recent data showed that Cbfa1 is also highly expressed in early stages of tooth development and is involved in crown morphogenesis and cytodifferentiation of odontoblasts. Here we report the mRNA expression and protein localization of Cbfa1 in the mouse dentition in (later) stage...

Our immunohistochemical study shows that atrial natriuretic peptide (ANP) is present in both human fetal and adult parotid gland. In the fetuses ANP is localized in cell clusters, while in adult parotid gland, the ANP is seen only in the wall of intra- and extralobular ducts. The results suggest that ANP might play a role in the differentiation of the parotid gland similarly as in brain and tha...

Sialometaplasia, squamous metaplasia of salivary gland lobules, is a benign condition occasionally presenting with lesions clinically simulating malignancy. "Necrotising sialometaplasia", recognised by lobular infarction, necrosis, and simultaneous squamous metaplasia of ducts and acini is a well known condition. There are only a few reports of the "proliferative type of sialometaplasia", which...

We report the case of a patient who presented with cystic lymphoid hyperplasia of the right parotid gland as the index diagnosis of HIV infection. Histological examination of the excised parotid gland revealed a solid-cystic lymphoepithelial lesion with a non-keratinous squamous epithelium, which grew into the lymphoid component via anastomosing cords and islands. These anastomosing cords and i...

In order to ascribe a blood feeding function to the saliva of mosquitoes, we determined whether this secretion may limit the initial probing phase of biting behaviour. The probing of hosts was indeed prolonged when the salivary ducts were severed, but this prolongation was absent when mosquitoes were fed on an artificial meal contained beneath a membrane. In vitro, turbidometric assays demonstr...