نتایج جستجو برای: salinomycin
تعداد نتایج: 526 فیلتر نتایج به سال:
The relationship between oocyst dose and lesion score was evaluated in trials involving five field isolates each of Eimeria acervulina, Eimeria maxima, and Eimeria tenella. Each trial included an uninfected, unmedicated treatment, and at least three treatments of unmedicated birds given different doses of oocysts from a single isolate. In four trials each with E. acervulina and E. tenella, and ...
Antibiotics in the environment are a potential threat to environmental ecosystems as well as human health and safety. Antibiotics are designed to have a biological effect at low doses, and the low levels detected in the environment have turned focus on the need for more research on environmental occurrence and fate, to assess the risk and requirement for future regulation. This article describe...
Ovarian cancer is the fifth most lethal malignancy in women. The standard treatment of this disease is chemotherapy which is, however, often inefficient. The failure of chemotherapy is due to the developing multidrug resistance and the presence of cancer stem cells. This article describes research on new drugs, which can overcome these limitations. Some of the substances which are effective in ...
The drug target profile proposed by the Medicines for Malaria Venture for a malaria elimination/eradication policy focuses on molecules active on both asexual and sexual stages of Plasmodium, thus with both curative and transmission-blocking activities. The aim of the present work was to investigate whether the class of monovalent ionophores, which includes drugs used in veterinary medicine and...
This experiment was carried out to study the effect of ionophore drugs (Salinomycin, Lasalocid and their combination) on the performance of broiler chicks. Also their relationship with methionine (three levels) was evaluated. 1215 one-day-old commercial broiler chicks (Arian) were divided into 81 groups, 15 chicks per group, and tested in a completely randomized design with a 3×3×3 factorial ex...
Prostate cancer initially responds to hormone-based therapeutics such as anti-androgen treatment or chemotherapeutics but eventually becomes resistant. Novel treatment options are therefore urgently needed. This thesis study applied a high-throughput screen of 4910 known drugs and drug-like small molecules to identify compounds that selectively inhibit growth of prostate cancer cells. In additi...
A total of 65 toxigenic Clostridium difficile strains isolated from patients with antibiotic-associated diarrhea were tested for susceptibility to avilamycin, flavomycin, monensin, and salinomycin. Except for flavomycin the substances showed in vitro efficacy comparable to reports of the currently most commonly used drugs for treatment of C. difficile. This indicates that these old compounds ma...
In pig production, the terms "growth promoter", "performance enhancer", and "digestive enhancer" include a diverse range of products ranging from simple chemicals (copper salts) to chemically produced antibacterial compounds (carbadox) to antibiotics (tylosin, avilamycin, salinomycin, virginiamycin). Most of the antibiotic group are produced during a fermentation process by yeasts, moulds, and ...
Acute myeloid leukemia (AML) is a heterogeneous and intrinsically resistant stem cell neoplasm, occurring in about 14 000 patients the US annually. AML characterized by unbridled proliferation of progenitor cells block normal differentiation. Unfortunately, despite recent advances treatment, prognosis poor for almost all older adults half under age 60. Thus, novel effective therapies are urgent...
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