In many patients with chronic bronchitis and emphysema right and left ventricular ejection fractions (RVEF and LVEF) are reduced. A study was conducted using multiple gated equilibrium radionuclide ventriculography to compare the effects of oral salbutamol 4 mg and pirbuterol 15 mg on cardiac function in 12 patients with chronic bronchitis (forced expiratory volume in one second 0.86 (SEM 0.12)...

Objective: To evaluate and compare the protective effects of salbutamol and montelukast in amelioration of insulin induced airway hyper-reactivity on isolated tracheal smooth muscle of guinea pig in vitro. Study Design: Laboratory based randomized control trials (Experimental study). Place and Duration of Study: Pharmacology Department and Centre for Research in Experimental and Applied Medicin...

The possible role of β-2 adrenergic receptors in modulation of inflammatory and nociceptive conditions suggests that the β-2 adrenergic receptor agonist, salbutamol, may have beneficial anti-inflammatory and analgesic effects. Therefore, in this study, we induced inflammatory and nociceptive responses with carrageenan-induced paw edema or cotton-pellet-induced granuloma models, both of which re...

OBJECTIVE To examine the pharmacological interaction of salmeterol and salbutamol and to derive an estimate of dose equivalence of salmeterol for airway and systemic effects in patients with asthma. DESIGN Randomised double blind crossover study. SUBJECTS 12 patients with mild asthma. INTERVENTION Placebo or salmeterol 50, 100, 200 micrograms given on separate days followed two hours late...

Background: This study aimed to evaluate the safety and efficacy of inhaled salbutamol for the treatment of Transient Tachypnea of the Newborn (TTN). Methods: Totally, 80 neonates with TTN were randomly assigned into two groups of treatment and placebo. The treatment and placebo groups received one dose of nebulized salbutamol (dose of 0.15 ml/kg in 2 ml of normal saline) and only 2 ml 0.9% no...

Formulation and evaluation of Salbutamol sulphate microspheres by solvent evaporation methodV.V Prasanth, Akashmoy Chakraborty, Sam T Mathew, Rinku Mathappan, V. Kamalakkannan

BACKGROUND Salmeterol is a potent selective beta 2 agonist that has been shown to have a duration of action in excess of 12 hours. In this study salmeterol and salbutamol were compared over a three month period with a further extension of nine months. METHODS Three hundred and eighty eight patients with mild to moderate reversible airways obstruction (forced expiratory volume in one second (F...

Nebulized salbutamol has been known to be an effective treatment of asthma for almost two decades [1] and nebulized bronchodilator therapy has now become firstline treatment of severe acute asthma in the Emergency Departments of most British hospitals [2]. This treatment was recommended as the most effective in 1972 [3J. but after the advent of intravenous salbutamol and terbutaline the choice ...

BACKGROUND Asthma is a common problem in children and, if inadequately controlled, may seriously diminish their quality of life. Inhaled short-acting beta2 agonists such as salbutamol are usually prescribed as 'reliever' medication to help control day-to-day symptoms such as wheeze. As with many medications currently prescribed for younger children (defined as those aged 2 years 6 months to 6 y...

BACKGROUND The administration of salbutamol is permitted only by inhalation by the International Olympic Committee (IOC) for the management of asthma and exercise-induced asthma in athletes. The establishment of criteria to distinguish between the (IOC) authorized use (inhaled) and the (IOC) prohibited use (oral) of salbutamol appeared possible using simultaneous evaluation of variables based o...