Superantigens (SAg) are a family of bacterial and viral proteins with strong immunostimulatory properties. SAg bound to major histocompatibility complex (MHC) class II molecules activate a high frequency of T cells and represent the most potent known activators of T cells to date. To explore the use of SAg for T cell-based tumor therapy we have created a tumor-reactive SAg by engineering a fusi...

We develop a novel preconditioning method for ridge regression, based on recent linear sketching methods. By equipping Stochastic Variance Reduced Gradient (SVRG) with this preconditioning process, we obtain a significant speed-up relative to fast stochastic methods such as SVRG, SDCA and SAG.

Elucidating the role of carbohydrate quality in human nutrition requires a greater understanding of how the physico-chemical characteristics of foods relate to their physiological properties. It was hypothesised that rapidly available glucose (RAG) and slowly available glucose (SAG), in vitro measures describing the rate of glucose release from foods, are the main determinants of glycaemic inde...

7 International Conference on Head-driven Phrase Structure Grammar, Berkeley 22 July 2000 Aims: 1⁄2 Supporting the ARG-ST / DEPS / VALENCE distinction 1⁄2 Working towards a theory of diathesis and diathetic paradigmatic relations in HPSG 1⁄2 Reconsidering phenomena that are sensitive to subject prominence 1⁄2 Possibilities of making compatible the insightful HPSG analyses of binding (Manning an...

---------------------------------------------------------------------***-------------------------------------------------------------------Abstract: – Dynamic voltage restorer (DVR) is the mostly used custom power device for improving power quality indices. The main function of DVR is to mitigate the problems of voltage sag and voltage swells. In this paper, DVR is used to control voltage sag a...

Due to a paucity of studies that synthesize structural, energetic, and functional analyses of a series of protein complexes representing distinct stages in an affinity maturation pathway, the biophysical basis for the molecular evolution of protein-protein interactions is poorly understood. Here, we combine crystal structures and binding-free energies of a series of variant superantigen (SAG)-m...

Voltage sag is one of the most severe power quality disturbances to be dealt with by industrial sector, as it can cause process disruptions and results in substantial economic loss. A short-term decreasein voltage lasting anywhere from milliseconds up a few seconds called sag. At present, wide range very flexible controllers, which capitalize on newly available electronics components, are emerg...

A method to grow high quality, single crystalline semiconductor material irrespective of the substrate would allow a cost-effective improvement to functionality and performance of optoelectronic devices. Recently, a novel type of substrate-insensitive growth process called Evolutionary Selection Selective Area Growth (ES-SAG) has been proposed. Here we report the use of X-ray microdiffraction t...

One of the most concerning disturbances affecting power quality are voltage sags. Their major source are short-circuits on the utility lines. Faults many kilometres from the disturbed process will generate a momentary voltage sag in the electrical environment to the end user. A reduction of the short-circuit current magnitude may lead to a substantial power quality improvement because the major...

Voltage sags normally do not cause equipment damage but can easily disrupt the operation of sensitive loads such as electronic Adjustable Speed Drives (ASD’s). Voltage sags cause a momentary decrease in DC-link voltage triggering an under voltage trip leading to nuisance tripping of adjustable speed drives (ASD’s) employed in continuous-process industries which contributes to loss in revenue. A...