Introduction S1 Pharmacological actions S2 Traumatic lesions and experimental cerebral oedema S2 Cerebral hypoxia and ischaemia S5 Synaptic transmission and neurotransmitter levels S13 Learning performance, memory and brain ageing S17 Experimental withdrawal syndrome and intoxications S19 Toxicity S20 Acute toxicity S20 Subacute toxicity S20 Chronic toxicity S20 Teratogenicity S20 Pharmacokinet...

S1 Supplementary Methods S3 S1.1 Implementation details . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S3 S1.1.1 Filtering procedure used in FastCMH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S4 S1.2 Theoretical aspects of FastCMH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S5 S1.2.1 p-value for the CMH te...

A diagonal polyacrylamide-dodecyl sulfate gel electrophoresis procedure is described. Its utility is related to the use of the reagent methyl-4-mercaptobutyrimidate as a protein-protein crosslinking reagent. Crosslinking with this reagent occurs through the formation of intermolecular disulfide bonds. Oxidized proteins are separated in one dimension by electrophoresis under non-reducing conditi...

Previous studies revealed that Honghu Lake was polluted by trace elements due to anthropogenic activities. This study investigated the spatial distribution of trace elements in Honghu Lake, and identified the major pollutants and control areas based on the fuzzy health risk assessment at screening level. The mean total content of trace elements in surface water decreased in the order of Zn (18....