“older people are an enormous asset to our societies, not only because a large majority of them continue to work in old age, but also because they convey social values to younger generations” dr. wesum asia/pacific regional conference on ageing 2012 the population ages 65 and over is expected to grow very rapidly in all parts of the world. over the next decades, the elderly population is projec...

objective(s):alzheimer's disease (ad) is the most common age-related neurodegenerative disorder. one of the hallmarks of ad is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. in this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in ad and tauopathies. unfortunately, the available syn...

abstract   backgrounds: pott's disease is a rare form of extrapulmonary tuberculosis, and presents with several clinical patterns. delay in diagnosis and management may cause serious complications. we conducted a retrospective study between 1991- 2006 to evaluate clinical presentation, radiologic and laboratory findings, and therapeutic approaches to spinal tuberculosis.   methods: we reviewed ...

introduction: estrogen is one of the gonadal hormones that has multiple beneficial actions in central nervous system and involves in learning and memory. alzheimer's disease (ad) is a progressive neurodegenerative disorder that impairs patient memory. the human nucleus basalis of meynert (nbm) is severely affected in alzheimer's disease. so in this study the effect of peripheral (intr...

a 38-year-old man with a history of recurrent genital ulceration initially diagnosed as genital herpes was admitted after presenting with paroxysmal nocturnal dyspnea. echocardiography revealed aneurysm formation of the sinus of valsalva. on diagnosis of an aneurysm of the sinus of valsalva associated with behçet's disease (bd), surgeon repaired the affected sinus only, and continuous steroid t...

meniere’s disease is the disorder of inner ear characterized by vertigo, tinnitus and sensorineural hearing loss. the vestibular evoked myogenic potential (vemp) test could be useful in the analysis of saccular function, and diagnosis of meniere’s disease. in this study, we’ve analyzed the saccular function, using vemp test in different groups of meniere’s disease. patients were categorized as ...

cognitive deficits such as impairments in attention, memory, information processing and executive functioning can be found in some parkinson's disease (pd) patients. recent studies suggested that pd drivers generally performed poorer than their healthy age-matched controls with regards to their cognitive and motor abilities during the psychometric testing. according to michon’s model of ca...

objective: the clinical value of igg anticardiolipin antibody in patients with behçet's disease with or without vascular thrombosis was evaluated.   methods: igg isotype of anticardiolipin (acl) antibody was assessed in 40 behçet's disease (bd) patients with venous or arterial thrombosis, 40 bd patients without venous or arterial thrombosis and 80 healthy subjects as controls. the lev...

background and objectives:traditional medicine is an important approach to achieve new therapeutic strategies in basic and clinical pharmacology. allium hirtifolium boiss. and astragalus hamosus l. have been mentioned in iranian traditional medicine references for a kind of dementia with features and symptoms similar to those of alzheimer's disease (ad). in the present study, the neuroprot...

bacground: wilson's disease is a rare autosomal recessive disorder characterized by toxic accumulation of copper in liver and brain. the disorder is caused by mutations in the atp7b gene, encoding a copper transporting p-type atpase. characterization of the spectrum of mutations in this gene is important both for diagnosis and genetic counseling of the families.materials and methods: we en...