Preliminary proteomics studies between tonic vs. phasic smooth muscles identified three distinct protein spots identified to be those of transgelin (SM22). The latter was found to be distinctly downregulated in the internal anal sphincter (IAS) vs. rectal smooth muscle (RSM) SMC. The major focus of the present studies was to examine the differential molecular control mechanisms by SM22 in the f...

Mulberry is one of the most widely used traditional Chinese medicines. Anthocyanins are the main bioactive components of mulberry, and possess important biological activities, such as antimicrobial, anti-inflammatory and antioxidant activities. This study investigated the ultrasound-assisted extraction (UAE) of anthocyanins from mulberry by using response surface methodology (RSM). The extracti...

This paper proposes Clock-RSM, a new state machine replication protocol that uses loosely synchronized physical clocks to totally order commands for geo-replicated services. Clock-RSM assumes realistic non-uniform latencies among replicas located at different data centers. It provides low-latency linearizable replication by overlapping 1) logging a command at a majority of replicas, 2) determin...

The resource space model (RSM) is a semantic data model based on orthogonal classification semantics for efficiently managing various resources in the future interconnection environment. This paper extends the RSM in theory by formalizing the resource space, investigating its characteristics from the perspective of set theory, defining the resource space schema and developing its normal forms. ...

BACKGROUND Whole blood gene expression-based molecular diagnostic tests are becoming increasingly available. Conventional tube-based methods for obtaining RNA from whole blood can be limited by phlebotomy, volume requirements, and RNA stability during transport and storage. A dried blood spot matrix for collecting high-quality RNA, called RNA Stabilizing Matrix (RSM), was evaluated against PAXg...

Reliability theory is used to assess the sensitivity of a passive flexion and active flexion of the human lower leg Finite Element (FE) models with Total Knee Replacement (TKR) to the variability in the input parameters of the respective FE models. The sensitivity of the active flexion simulating the stair ascent of the human lower leg FE model with TKR was presented before in [1,2] whereas now...

BACKGROUND Item response theory (IRT) is extensively used to develop adaptive instruments of health-related quality of life (HRQoL). However, each IRT model has its own function to estimate item and category parameters, and hence different results may be found using the same response categories with different IRT models. The present study used the Rasch rating scale model (RSM) to examine and r...

Laser marking is one of the well-developed technologies of materials processing. Laser marking is the best and most applied permanent marking method. The present research papers deals with the artificial neural network (ANN) and the response surface methodology (RSM) based mathematical modelling and also an optimization analysis on marking characteristics i.e., mark width, mark depth and mark i...

When information sequences are embedded into radar waveforms by means of coding diversity, the resulting radar emissions then change on a pulse-to-pulse basis during a coherent processing interval (CPI). As such, pulse compression of these different waveforms leads to different sidelobe structures, giving rise to range sidelobe modulation (RSM) of the clutter. The presence of RSM induces a part...