نتایج جستجو برای: route related toxicity

تعداد نتایج: 1332476  

2015
Jiri Minarik Petr Pavlicek Ludek Pour Tomas Pika Vladimir Maisnar Ivan Spicka Jiri Jarkovsky Marta Krejci Jaroslav Bacovsky Jakub Radocha Jan Straub Petr Kessler Marek Wrobel Lenka Walterova Michal Sykora Jarmila Obernauerova Lucie Brozova Evzen Gregora Dagmar Adamova Jaromir Gumulec Zdenek Adam Vlastimil Scudla Roman Hajek

OBJECTIVE Subcutaneous (SC) application of bortezomib has been recently introduced as a new application route in multiple myeloma (MM) patients. We performed an analysis to compare the outcomes of bortezomib-based therapy in multiple myeloma (MM) patients treated using either intravenous (IV) or subcutaneous (SC) route of administration. PATIENTS AND METHODS During January 2012 through Decemb...

Journal: :Toxicology 2010
Chandan Thomas Majid Moridani

A number of currently available vaccines have shown significant differences in the magnitude of immune responses and toxicity in individuals undergoing vaccination. A number of factors may be involved in the variations in immune responses, which include age, gender, race, amount and quality of the antigen, the dose administered and to some extent the route of administration, and genetics of imm...

Journal: Nanomedicine Journal 2016
M. Safari S. Arbabi Bidgoli S.M. Rezayat

Silver Nanoparticles (AgNPs) have gained considerable interests during the last decade due to their excellent antimicrobial activities. Despite their extensive use, the potential toxicity of these nanoparticles and possible mechanisms by which they may induce adverse reactions have not received sufficient attention and no specific biomarker exist to describe and quantify their toxic effects. Na...

2012
Chia Ju Chang Thing-Fong Tzeng Shorong-Shii Liou Yuan-Shiun Chang I-Min Liu

The objective of this study was to evaluate the acute and subacute toxicity (28 days) of the ethanol extract of Z. zerumbet rhizomes (EEZZ) via the oral route in Wistar rats of both sexes. In the acute toxicity study, Wistar rats were administered a single dose of 15 g kg(-1) of body weight by gavage, and were monitored for 14 days. EEZZ did not produce any toxic signs or deaths; the 50% lethal...

Journal: :Environmental toxicology and chemistry 2013
Paula S Tourinho Cornelis A M van Gestel Stephen Lofts Amadeu M V M Soares Susana Loureiro

The effects of soil pH on the toxicity of ZnO nanoparticles (NPs) to the terrestrial isopod Porcellionides pruinosus were evaluated. Isopods were exposed to a natural soil amended with CaCO3 to reach 3 different pH(CaCl2) levels (4.5, 6.2, and 7.3) and to standard LUFA 2.2 soil (pH 5.5) spiked with ZnO NPs (30 nm), non-nano ZnO (200 nm), and ionic Zn as ZnCl₂. Toxicity was expressed based on to...

Journal: :Anticancer research 2005
Keiichiro Ishibashi Kazuhiko Yoshimatsu Hajime Yokomizo Arihiro Umehara Kiyohito Yoshida Takashi Fujimoto Kiyo Watanabe Takao Katsube Yoshihiko Naritaka Kenji Ogawa

UNLABELLED In the present study, a retrospective investigation was conducted to determine whether or not it was possible to obtain a comparable survival time, response rate (RR) and modest toxicity combining low-dose leucovorin (LV) and 5-Fluorouracil (5-FU) (LV/5-FU) with hepatic arterial infusion (HAI) or systemic intravenous infusion (SI) for patients with unresectable liver metastasis from ...

Journal: :nanomedicine journal 0
m. safari department of medical nanotechnology, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) s. arbabi bidgoli department of toxicology and pharmacology, faculty of pharmacy, pharmaceutical sciences branch, islamic azad university, tehran, iranسازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (islamic azad university science and research branch) s.m. rezayat department of medical nanotechnology, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

silver nanoparticles (agnps) have gained considerable interests during the last decade due to their excellent antimicrobial activities. despite their extensive use, the potential toxicity of these nanoparticles and possible mechanisms by which they may induce adverse reactions have not received sufficient attention and no specific biomarker exist to describe and quantify their toxic effects. na...

2012
Jan M. Wiener Hana Kmecova Olivier de Condappa

Retracing a recently traveled route is a frequent navigation task when learning novel routes or exploring unfamiliar environments. In the present study we utilized virtual environments technology to investigate age-related differences in repeating and retracing a learned route. In the training phase of the experiment participants were guided along a route consisting of multiple intersections ea...

Journal: :iranian journal of medical sciences 0
saied karbalay-doust ali noorafshan

background: there is extensive variety of chemical compounds with antiulcer activity, which are isolated from medicinal plants. matricaria chamomilla or matricaria recutita or german chamomile, also spelled chamomile (mc), is one of the most widely used medicinal plants. in the present study, the extract of mc flowers was evaluated for antiulcerogenic activity and acute toxicity profile.   meth...

Journal: :Blood purification 2011
Richard Amerling Claudio Ronco Martin Kuhlman James F Winchester

The arteriovenous fistula (AVF) has been a mainstay of hemodialysis treatments and the preferred access route since its inception in the 1960s, due to its longevity and resistance to infection. However, the AVF is not benign. There is significant primary failure, as well as cardiac, vascular, and other, less well recognized, complications. Together, they represent toxicity, to which considerabl...

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