Background: Non-melanoma skin cancer is the most common malignant tumor in humans. The role of ultraviolet radiation is well-known in the pathogenesis of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). CD10 is a zinc-dependent metallopeptidase known as common acute lymphoblastic leukemia antigen (CALLA). Although CD10 expression has been investigated in some cutaneous tu...

incidence, causes and outcomes of ventilator-associated pneumonia in the medical intensive care unit    amri meleh p [1] , bayani m [2] *, nikbakhsh n [3] , pourhassan a [4] , marzban m [5] , shirkhani z [6] , damavandi f [7] , soleimaniyan ss [8]     received: 15 may , 2013 accepted: 14 aug , 2013    abstract  background & aims : ventilator associated pneumonia is one of the most common h ospi...

mechanisms, and applications. Genes Dev 2010;24:2239–2263. 3. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131: 861–872. 4. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, et al. Induced pluripotent st...

Background: During the COVID-19 pandemic, the presence of ocular symptoms was common in COVID-19 patients, which can cause secondary complications in the treatment of ocular diseases. On the other hand, obesity can cause secondary symptoms in infectious diseases by impairing the function of the immune system, which indicates the relationship between involvement of different tissues and dysfunct...

Two overlapping yet distinct sets of developments influence Iran’s position in the Persian Gulf region, one having to do with Islamic Republic’s own policies and other structural factors that are largely beyond control policymakers Tehran. In terms policy, Tehran’s regional relations shaped by a confluence security as well diplomatic priorities. At broadest level, resulting policy output amount...

Dupilumab, a mAb targeting IL-4 receptor alpha (IL-4R?), markedly improves disease severity in patients with atopic dermatitis. However, the effect of IL-4R? blockade on dynamics circulating skin-homing T cells, which are crucial players pathologic mechanism dermatitis, has not been studied yet. In addition, it remains unknown whether dupilumab treatment induces long-lasting T- and B-cell polar...