نتایج جستجو برای: roth 801

تعداد نتایج: 6428  

Journal: :Brain research 1993
J S Mogil P Marek R Yirmiya H Balian B Sadowski A N Taylor J C Liebeskind

Recent evidence from our laboratory suggests that the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 (dizocilpine) selectively antagonizes non-opioid (i.e. naloxone-insensitive) mechanisms of stress-induced analgesia in mice. For example, we have recently demonstrated that a low dose of MK-801 (0.075 mg/kg, i.p.) antagonizes the non-opioid component of a mixed opioid/non-opioid swim str...

Journal: :The Journal of pharmacology and experimental therapeutics 1997
C Bolton C Paul

Increased permeability of the blood-brain barrier (BBB) is a characteristic of the demyelinating disease multiple sclerosis and the animal counterpart experimental allergic encephalomyelitis (EAE). In physically traumatized cerebral tissue neurovascular damage, linked with activation of the cerebroendothelial-bound N-methyl-D-aspartate receptor, can be treated with the antagonist MK-801. We hav...

Journal: :Journal of applied physiology 2002
Deborah N D'Souza Richard E Harlan Meredith M Garcia

Rats show gender differences in responses to morphine and the N-methyl-D-aspartate receptor antagonist dizocilpine (MK-801); the role of sex steroids in mediating these differences is unclear. We tested the overall hypothesis that circulating gonadal steroids determine the gender differences in morphine- and MK-801-induced behavior and c-Fos expression. Morphine caused a greater expression of c...

Journal: :Neurobiology of learning and memory 2015
Michael Guidi Asha Rani Semir Karic Barrett Severance Ashok Kumar Thomas C Foster

A decrease in N-methyl-D-aspartate receptor (NMDAR) function is associated with age-related cognitive impairments. However, NMDAR antagonists are prescribed for cognitive decline associated with age-related neurodegenerative disease, raising questions as to the role of NMDAR activity in cognitive function during aging. The current studies examined effects of NMDAR blockade on cognitive task tha...

Journal: :Journal of applied physiology 2005
Stephen G Reid Frank L Powell

Chronic hypoxia increases the sensitivity of the central nervous system to afferent input from carotid body chemoreceptors. We hypothesized that this process involves N-methyl-D-aspartate (NMDA) receptor-mediated mechanisms and predicted that chronic hypoxia would change the effect of the NMDA receptor blocker dizocilpine (MK-801) on the poikilocapnic hypoxic ventilatory response (HVR). Male Sp...

Journal: :Pharmacological reports : PR 2013
Zofia Rogóż

BACKGROUND Several clinical reports have suggested that the mirtazapine-induced augmentation of risperidone activity may effectively improve treatment of the negative and certain cognitive symptoms of schizophrenia. METHODS The aim of the present study was to evaluate the effect of mirtazapine and risperidone, given separately or jointly, on the impact of MK-801(an NMDA receptor antagonist), ...

2012
Yaoyu Li An’an Yang Tingting Zhu Zhao Liu Siwei You Kwok-Fai So

This study investigated the effects of daily intraperitoneal injections of N-methyl-D-aspartate receptor antagonist MK-801 and nitric oxide synthase inhibitor nitro-L-arginine (L-NA) on the survival of retinal ganglion cells (RGCs) at 1 and 2 weeks after unilateral optic nerve transection in adult hamsters. The left optic nerves of all animals were transected intraorbitally 1 mm from the optic ...

Journal: :Journal of Korean Medical Science 2003
Sun Young Ko Jae Won Shim Sung Shin Kim Mi Jung Kim Yun Sil Chang Won Soon Park Son Moon Shin Mun Hyang Lee

We evaluated the efficacy of non-competitive N-methyl-D-aspartate receptor antagonist MK-801 (dizocilpine) as an adjuvant therapy in experimental neonal bacterial meningitis. Meningitis was induced by injecting 10(6) colony forming units of Escherichia coli into the cisterna magna. MK-801 3 mg/kg was given as a bolus intravenous injection, 30 min before the induction of meningitis. MK-801 did n...

Journal: :Pharmacology, biochemistry, and behavior 2001
S B Harrod R W Flint D C Riccio

Two experiments using a state-dependent retention (SDR) design determined whether MK-801 blocked the acquisition and retention of an avoidance response. In Experiments 1 and 2, rats were trained and tested 30 min after injections of either saline or MK-801 (0.05 and 0.10 mg/kg, respectively). Two minutes after training, subjects were immediately tested, and in both experiments, the avoidance re...

2014
François Séguin

Assignment 1 François Séguin Question 1 (a) We know that for any simple graph X, v∈V (X) d(v) = 2 |E(X)|. In particular, the sum must be even. Here, summing over all the degrees of the vertices yield a total degree of 41, which is odd. Therefore, there is no such simple graph. The Handshake Lemma for bipartite graphs states that, if A and B are the disjoint independent set of vertices of the gr...

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