نتایج جستجو برای: rora
تعداد نتایج: 204 فیلتر نتایج به سال:
The interleukin-23 (IL-23) pathway plays a critical role in the pathogenesis of multiple chronic inflammatory disorders, however, inter-individual variability in IL-23-induced signal transduction in circulating human lymphocytes has not been well-defined. In this study, we observed marked, reproducible inter-individual differences in IL-23 responsiveness (measured by STAT3 phosphorylation) in p...
BACKGROUND The aim of this study was to study the effects of 1-alpha,25-dihydroxy-cholecalcifero (1,25(OH)2D3) on liver fibrosis and the generation of Th17 cells in vivo and in vitro. MATERIAL AND METHODS Thirty C57 mice were randomly divided into control, model, and treatment groups. Hepatic fibrosis was induced by subcutaneous injection of CCl4. Liver fibrosis condition was evaluated through ...
An important segment of the population relies on agriculture for their living, and it has long been a key contributor to GDP India. Because is one country's largest private industries connected variety production market sectors, holds most significant place in Indian economy (Sengupta, n.d.). The projections from Ministry Statistics & Programme Implementation (MoSPI) indicate that GVA agric...
Cleft lip with or without cleft palate (CL/P) and only (CPO) are congenital birth defects where the upper and/or fail to fuse properly during embryonic facial development. CL/P CPO fall under larger category of orofacial clefts (OFCs), which affect ~1.2/1000 live births world-wide imposes significant social financial burdens on affected individuals their families. The etiology is complex likely...
Bipolar disorder (BD) is a chronic and burdensome psychiatric disease, characterized by variations in mood energy. The literature has consistently demonstrated an association between BD childhood maltreatment (CM), genetic variants of circadian genes have been associated with increased vulnerability to develop BD. In this context, environmental factors such as CM may also contribute the suscept...
Several studies have identified nearly 40 different type 2 diabetes susceptibility loci, mainly in European populations, but few of them have been evaluated in the Mexican population. The aim of this study was to examine the extent to which 24 common genetic variants previously associated with type 2 diabetes are associated in Mexican Mestizos. Twenty-four single nucleotide polymorphisms (SNPs)...
The retinoic acid receptor-related orphan receptor α (RORα) is a member of the nuclear receptor superfamily of transcription factors that plays an important role in regulation of the circadian rhythm and metabolism. Mice lacking a functional RORα display a range of metabolic abnormalities including decreased serum cholesterol and plasma triglycerides. Citrate synthase (CS) is a key enzyme of th...
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