In 1994, Richard J. Herrnstein and Charles Murray published The Bell Curve, a book that used a range of statistical techniques to posit racial differences in intelligence (Herrnstein & Murray, 1994). According to Hammonds (2006), there have been two different types of reactions to the publication. On one hand, the book generated a host of detailed critiques that were devoted to carefully dissec...

There have been numerous recent reports documenting phosphorylation of DNA-binding proteins [Montminy and Bilezikjian (1987); Sorger, Lewis, and Pelham (1987); Hoeffler, Kovelman, and Roeder (1988); Jones et al. (1988); Prywes et al. (1988); Sorger and Pelham (1988); Yamamoto et al. (1988)], and the transcriptional regulatory activity of at least one of these proteins appears to be modulated by...

Saframycin A (SafA) is a member of a class of natural products with potent antiproliferative effects in leukemia- and tumor-derived cells. This activity is frequently conjectured to derive from the ability of saframycins to covalently modify duplex DNA. We used a DNA-linked affinity purification technique to identify GAPDH as a protein target of DNA-small molecule adducts of several members of ...

There have been numerous recent reports documenting phosphorylation of DNA-binding proteins [Montminy and Bilezikjian (1987); Sorger, Lewis, and Pelham (1987); Hoeffler, Kovelman, and Roeder (1988); Jones et al. (1988); Prywes et al. (1988); Sorger and Pelham (1988); Yamamoto et al. (1988)], and the transcriptional regulatory activity of at least one of these proteins appears to be modulated by...

Association between disease and genetic polymorphisms often contributes critical information in our search for the genetic components of common diseases. Devlin and Roeder [1999: Biometrics 55:997-1004] introduced genomic control, a statistical method that overcomes a drawback to the use of population-based samples for tests of association, namely spurious associations induced by population str...

OBJECTIVE To report a ventral abdominal approach and a ligating loop technique for laparoscopic cryptorchidectomy in horses. STUDY DESIGN Prospective. SAMPLE POPULATION Six horses, aged 1 to 5 years, with retained testes. METHODS One laparoscopic portal and three to four instrument portals were used for ventral abdominal laparoscopic cryptorchidectomy. Laparoscopic instruments were used t...

Crossley J R, Elliott R B, Smith P A. Dried-blood spot screening for cystic fibrosis in the newborn. Lancet 1979; i: 472-4. 2 Crossley J R, Smith P A, Edgar B W, Gluckman P D, Elliott R B. Neonatal screening for cystic fibrosis using immunoreactive trypsin assay in dried-blood spots. Clin ChimActa 1981; 113: 111-21. 3 Adriaenssens K, Janssens H, Van Soom H. Letter: Two tier screen for cystic fi...

We present the R package hdlm, created to facilitate the study of high dimensional datasets. Our emphasis is on the production of regression tables and a class ‘hdlm’ for which new extensions can be easily written. We model our work on the functionality given for linear and generalized linear models from the functions lm and glm in the recommended package stats. Reasonable default options have ...

The chemical composition of the fluid surrounding the cells of the central nervous system of Periplaneta has been shown to differ from that of the haemolymph, due to a Donnan equilibrium which maintains an excess of inorganic cations in the extracellular fluid (Treherne, 1962 a, b). In view of the demonstrated permeability of the nerve sheath to ions and molecules (Treherne, 1961 a, b) it was s...

The multiprotein Mediator complex is a coactivator required for transcriptional activation of RNA polymerase II transcribed genes by DNA binding transcription factors. We previously partially purified a Med8-containing Mediator complex from rat liver nuclei (Brower, C. S., Sato, S., Tomomori-Sato, C., Kamura, T., Pause, A., Stearman, R., Klausner, R. D., Malik, S., Lane, W. S., Sorokina, I., Ro...