AIMS To evaluate different algorithms used to analyse retinal nerve fibre layer thickness (RNFL) data obtained by scanning laser polarimetry, in order to compare their relative abilities to discriminate between patients with glaucomatous localised nerve fibre layer defects and normal subjects. METHODS 48 eyes of 48 glaucomatous patients with localised RNFL defects and 53 eyes of 53 healthy su...

Receiver operating characteristic (ROC) curve has been widely used in medical science for its ability to measure the accuracy of diagnostic tests under the gold standard. However, in a complicated medical practice, a gold standard test can be invasive, expensive, and its result may not always be available for all the subjects under study. Thus, a gold standard test is implemented only when it i...

In this paper we review the Receiver Operating Characteristic ROC curve and the test statistic in relation to the analysis of a confusion matrix We then show how these two methods are related and propose an extension to the ROC curve so that it shows contours of values These contours can be used to provide further insight into the appropriate setting of the decision threshold for a particular a...

This review provides the basic principle and rational for ROC analysis of rating and continuous diagnostic test results versus a gold standard. Derived indexes of accuracy, in particular area under the curve (AUC) has a meaningful interpretation for disease classification from healthy subjects. The methods of estimate of AUC and its testing in single diagnostic test and also comparative studies...

Background and Objectives: Gestational Diabetes Mellitus (GDM) is the most common metabolic disorder in pregnancy. In case of early detection, some of its complications can be prevented. The aim of this study was to investigate early prediction of GDM by logistic regression (LR), discriminant analysis (DA), decision tree (DT) and perceptron artificial neural network (ANN) and to compare these m...

Abstract Background: Recent studies have suggested that oxidative stress (OS) may have a contribution in the pathogenesis of endometriosis. However, the results of previous studies regarding OS in endometriosis are controversial. The objective of this study was to compare the serum levels of OS markers in endometriosis versus the control group. Methods: This case-control study was carried out...

Biomarkers have become essential tools for proper diagnosis and treatment of a wide range of illnesses, including cancer, diabetes, and infectious diseases. The growing need for rigorous evaluation of new biomarkers for medical practice has spurred the development and characterization of statistical methods for diagnostic accuracy. The receiver operating characteristic (ROC) curve is the standa...

RESEARCH DESIGN ANDMETHODSdA total of 339 subjects from the Diabetes Prevention Parenteral Trial–Type 1, who were islet cell antibody (ICA)-positive, with low first-phase insulin response (FPIR) and/or abnormal glucose tolerance at baseline, were followed until clinical diabetes onset or study end (5-year follow-up). The prognostic performance of biomarkers was estimated using receiver operatin...

Clinical accuracy, defined as the ability to discriminate between states of health, is the fundamental property of any diagnostic test or system. It is readily expressed as clinical sensitivity and specificity, and elegantly represented by the receiver operating characteristic (ROC) curve. To demonstrate the use of ROC curves, we reexamine a study of the ability of serum lipid and apolipoprotei...