The present study examined the role of the PRDI-BF1-RIZ (PR) domain of tumor suppressor retinoblastoma protein-interacting zinc finger gene 1 (RIZ1) as an anticancer domain and its ability to induce apoptosis in esophageal squamous cell carcinoma (ESCC) cells. The TE13 ESCC cell line was transfected with pcDNA3.1(+) eukaryotic expression vectors bearing the open reading frames of either the hum...

Germ cell tumors (GCTs) are a heterogeneous group of tumors occurring in gonadal and extragonadal locations. GCTs are hypothesized to arise from primordial germ cells (PGCs), which fail to differentiate. One recently identified susceptibility loci for human GCT is PR (PRDI-BF1 and RIZ) domain proteins 14 (PRDM14). PRDM14 is expressed in early primate PGCs and is repressed as PGCs differentiate....

PRDM (PRDI-BF1 and RIZ homology domain containing) protein family members are characterized by the presence of a PR domain and a variable number of Zn-finger repeats. Experimental evidence has shown that the PRDM proteins play an important role in gene expression regulation, modifying the chromatin structure either directly, through the intrinsic methyltransferase activity, or indirectly throug...

______________________ Dr. Omar Shahabudin McDoom is a Lecturer in Comparative Politics at the London School of Economics. This report has benefited from suggestions by the WDR 2011 core team, as well as from the World Bank’s Rwanda country office. Comments were received from Gérard Prunier, Peter Uvin (Professor of International Humanitarian Studies, The Fletcher School), and Scott Straus (Ass...

the date of receipt and acceptance should be inserted later Abstract. We present UBV RIz 0 photometry of the gra-vitational lens candidate CLASS B1152+119 obtained with the Nordic Optical Telescope. The two QSO components are resolved in the B, V , R, I and z 0 bands connrming the lensing nature of the system. The z = 0:44 lens galaxy is clearly detected in B, R, I and z 0 and its position is f...

We summarize the results from analyzing six clusters of galaxies at 0.14 < z < 0.40 observed with the Hubble Space Telescope Advanced Camera for Surveys. We derive deep composite luminosity functions in B, g, V, r, i and z down to absolute magnitude of ∼ -14 + 5 log h mag. The luminosity functions are fitted by a single Schechter function with M∗ BgV riz = −19.8, −20.9, −21.9, −22.0, −21.7, and...

L’autosuffisance en riz poursuivie par l’État du Sénégal depuis l’Indépendance a motivé des investissements colossaux dans le Delta fleuve Sénégal, au nord pays. Cet article évalue la contribution Projet de promotion partenariat rizicole (3PRD) aux dynamiques organisationnelles et techniques. L’importance ce projet repose sur public-privé, un paradigme récent monde développement l’agriculture i...

Through alternative promoter usage, human retinoblastoma protein-interacting zinc finger gene RIZ encodes two different protein products, RIZ1 and RIZ2, which have been identified to be a tumor suppressor and a proto-oncoprotein, respectively. Structurally, the two protein products share the same amino acid sequences except that RIZ2 lacks an N-terminal PR domain with methyltransferase activity...