We report herein a radical-mediated amination of cyclopropenes. The transformation proceeds through cleavage the three-membered ring after addition an azide radical on strained double bond and leads to tetrasubstituted alkenyl nitrile derivatives upon loss N2. With 1,2-diaryl substituted cyclopropenes, this methodology could be extended one-pot synthesis highly functionalized polycyclic aromati...

A fundamental goal of photochemistry is to understand how structural features a chromophore can make specific bonds within molecule prone cleavage by light, or photolabile. The meta effect an example regiochemical explanation for photolability, in which electron donating groups on aromatic ring cause photolability selectively at the position. Here, we show, using containing one with meta-methox...

What is the contractile ring? During cell division, the contractile ring generates the constricting force to separate one cell into two cells. Formed during cytokinesis, the last step of cell division, the contractile ring is composed of filamentous actin (F-actin) and the motor protein myosin-2, along with additional structural and regulatory proteins. The contractile ring forms under the surf...

Quinolinic acid (pyridine-cr , /3-dicarboxylic acid) has been isolated from rat urine after administration of tryptophan to rats (1). It has been suggested that quinolinic acid is formed via 3-hydroxyanthranilic acid by oxidative cleavage of the benzene ring in the 3-4 position, followed by closure incorporating the amino nitrogen in a pyridine ring (1). In this paper are reported the results o...

The metabolism of 5-aminosalicylate (5AS) by a bacterial strain, Pseudomonas sp. BN9, was studied. Intact cells of Pseudomonas sp. BN9 grown with 5AS oxidized 5AS and 2,5-dihydroxybenzoate (gentisate), whereas cells grown with gentisate oxidized only the growth substrate of all substituted salicylates tested. Cell extracts from Pseudomonas sp. BN9 catalysed the stoichiometric reaction of 1 mol ...

Four hitherto undescribed Clostridium strains capable of cleaving the C ring of quercetin, kaempferol, and naringenin at C-3-C-4 were isolated from the fecal flora of humans. None of the strains cleaved catechin. C-ring fission occurred when the substrate was either in solution or in suspension. Mixed cultures of flavonoid-hydrolyzing bacteria, flavonoid-cleaving bacteria, and Escherichia coli,...

Vismodegib (Erivedge, GDC-0449) is a first-in-class, orally administered small-molecule Hedgehog pathway inhibitor that is approved for the treatment of advanced basal cell carcinoma. Previously, we reported results from preclinical and clinical radiolabeled mass balance studies in which we determined that metabolism is the main route of vismodegib elimination. The metabolites of vismodegib are...

Dennis G. Brown* and William J. Hughes Department of Chemistry, University of Idaho, Moscow, Idaho, USA 83843 Z. Naturforsch. 36b, 1324-1330 (1981); received March 23, 1981 Dioxygenase Model, Copper, Catechol The complex (3-n-nonylcatecholato)(l,10-phenanthroline)copper(II) reacts with molecular oxygen to give an isomeric mixture of 2-n-nonylmuconic acid and several secondary oxidation products...