Extensive misexpression studies were carried out to explore the roles played by Tbx5, the expression of which is excluded from the right ventricle (RV) during cardiogenesis. When Tbx5 was misexpressed ubiquitously, ventricular septum was not formed, resulting in a single ventricle. In such heart, left ventricle (LV)-specific ANF gene was induced. In search of the putative RV factor(s), we have ...

Introduction:Asthma is the most common chronic inflammatory condition affecting the lower airways among children. Asthma may influence right ventricular (RV) function and patients may develop right ventricular hypertrophy, pulmonary hypertension and cor pulmonale. The main objective of this study is to determine RV dysfunction in asymptomatic asthmatic children as detected by ti...

BACKGROUND Right ventricular dysfunction has been observed in uremic patients receiving percutaneous transluminal angioplasty (PTA). This prospective study focuses on the impact of tissue Doppler imaging echocardiographic parameters on assessing right ventricle function in uremic patients post PTA of dysfunctional hemodialysis access. METHODS Sixty uremic patients were divided into two groups...

Methods Fifty patients undergoing clinically indicated right heart catheterization were prospectively recruited to a research CMR within 5 hours of catheterization. Majority of the heart failure cases were due to left heart failure. SSFP cine images were acquired to evaluate RV regional and global function. RV longitudinal and long axis radial strains were derived from the 4-chamber cine, and m...

During exercise, the right ventricle is exposed to a disproportionally higher wall stress than left ventricle, which further exaggerated under hypoxia. In this study, we showed that 12-wk high-intensity running hypoxic exercise training induced right-sided structural remodeling, was, in part, related baseline cardiac increase RV fractional area change acute exercise. These data suggest response...

The echocardiogram showed marked right heart chamber dilation (right ventricle ‐ RV 52 mm), a slight increase of the left atrium (45 mm), systolic blood pressure of 44 mmHg in the RV. The ascending aorta was normal (37 mm) and showed no myocardial hypertrophy (septum/posterior wall of 11 mm). Left ventricular function (75%) and size (39 mm) were normal. TEE showed major discontinuity of the atr...

The function of the right ventricle (RV) determines the fate of patients with pulmonary hypertension (PH). This already became apparent from the first registry of patients with pulmonary arterial hypertension (PAH) showing that right ventricular parameters rather than (arterial) load parameters determine prognosis. In more recent years it has been recognized that load dependent right ventricula...

OBJECTIVE Exercise thallium-201 (201T1) single photon emission computed tomography (SPECT) has been used to detect potential ischaemia in the left ventricular myocardium but not in the right ventricle. The purpose of this study was to establish the clinical usefulness of a right ventricular polar map of 201T1 SPECT for visualisation of exercise-induced right ventricular ischaemia. METHODS Myo...

Background The fundamental abnormality of restrictive right ventricle (RV) physiology is reduced RV compliance as a result of chronic increase in pressure overload. In this study, we test the hypothesis that the persistence of Restrictive RV physiology after balloon pulmonary valvoplasty (BPV) is related to RV fibrosis assessed by Gadolinium-DTPA delayed-enhancement magnetic resonance imaging (...

BACKGROUND Recent studies have reported that obstructive sleep apnea (OSA) patients present alterations in right ventricular (RV) structure and function. However, large randomized controlled trials evaluating the impact of OSA on the right ventricle are lacking. METHODS A comprehensive electronic database (PubMed, Web of Science, and Google Scholar) and reference search up to October 30, 2016...