IMPORTANCE Thrombocytopenia and intraventricular hemorrhage (IVH) are common among very-low-birth-weight (VLBW) infants. Survey results suggest that US neonatologists frequently administer platelet transfusions to VLBW infants with mild to moderate thrombocytopenia. OBJECTIVES To characterize platelet transfusion practices in US neonatal intensive care units (NICUs), to determine whether seve...

Current clinical application of platelet-rich plasma is showing a trend toward multiple treatments. The goal of this study was to show the benefit of interval platelet-rich plasma application in the healing and recovery of human tenocytes using an in vitro cell model. Eight volunteers (6 men and 2 women) were included in this study (mean±SD age, 31.6±10.9 years). Venous blood was collected from...

INTRODUCTION Hyperbaric oxygen and platelet-rich plasma are used in the treatment of diabetic wounds. The aim of this study is to evaluate the effects of hyperbaric oxygen therapy and autologous platelet concentrates in healing diabetic wounds. MATERIAL AND METHODS Thirty-six female Wistar albino rats were used in this study. Diabetes mellitus was induced chemically with an intraperitoneal in...

Background: With the increase in life expectancy, middle aged and elderly people comprise a substantial percentage of the population worldwide. Since aging often manifests itself in the human skin, skin rejuvenation methods have gained a lot of popularity. Current medical modalities such as botulinum toxininjection, fillers, and laser therapy can provide symptomatic relief of skin aging s...

perishability of blood products as well as uncertainty in demand amounts complicate the management of blood supply for blood centers. this paper addresses a mixed-integer linear programming model for blood platelets production planning while integrating the processes of blood collection as well as production/testing, inventory control and distribution. whole blood-derived production methods for...

statement of problem: reconstruction methods are an essential prerequisite for functional rehabilitation of the stomatognathic system. platelet-rich plasma (prp) offers a new and potentially useful adjunct to bone substitute materials (e.g. xenografts) in oral and maxillofacial bone and implant reconstructive surgery. purpose: an animal study was carried out to investigate the influence of prp ...

objective: to determine the effects of local administration of platelet rich plasma (prp) on peripheral nerve regeneration in rat sciatic nerve transection model. methods: forty-five male white wistar rats were randomized into three experimental groups (n = 15): normal control group (nc), silicon group (sil), prp treated group (sil/prp). in nc group left sciatic nerve was exposed through a glut...

We report a case of idiopathic thrombocytopenic purpura (ITP) accompanied by steroid-induced avascular necrosis of the femoral head in a 68-year-old woman. Extremely low platelet counts of ITP patients prohibit any surgical interventions. Her platelet count was 25,000/μL. We performed a total hip arthroplasty with high-dose immunoglobulin therapy and transfusion of platelet concentrates. Her pl...

OBJECTIVE The objective of this investigation was to establish the effectiveness of sustained-release platelet-rich plasma (PRP) on perfusion and neovascularization in diabetic murine hind limb ischemia. METHODS After surgery in streptozotocin-induced diabetic mice, the mice were randomly assigned to the following 4 experimental groups: control (C), 100 μl of the sustained-release form of pla...

The current study aims to evaluate the macroscopic and histological effects of autologous mesenchymal stem cells (MSC) and platelet-rich plasma on knee articular cartilage regeneration in an experimental model of osteoarthritis. Twenty-four rabbits were randomly divided into four groups: control group, platelet-rich plasma group, autologous MSC undifferentiated group, and autologous MSC differe...