“Click” chemistry has become an efficient avenue to unimolecular polymeric nanoparticles through the self-crosslinking of individual polymer chains containing appropriate functional groups. Herein we report the synthesis of ultra-small (7 nm in size) polymethyl methacrylate (PMMA) nanoparticles (NPs) by the “metal-free” cross-linking of PMMA-precursor chains prepared by reversible addition-frag...

Small-angle neutron scattering (SANS) studies of reversible addition-fragmentation chain transfer (RAFT) microemulsion polymerizations of butyl acrylate and 2-ethylhexyl acrylate with the RAFT agent methyl2-(O-ethylxanthyl)propionate (MOEP) allow the observed rate retardation to be attributed to slow fragmentation of the macro-RAFT radical. Microemulsion polymerization allows the RAFT mechanism...

This article is the first comprehensive review on the study and use of vinyl ester monomers in reversible addition fragmentation chain transfer (RAFT) polymerization. It covers all the synthetic aspects associated with the definition of precision polymers comprising poly(vinyl ester) building blocks, such as the choice of RAFT agent and reaction conditions in order to progress from simple to co...

A series of well-defined copolymer brushes, PS-g-P3HT, composed of a hydrophobic coil-like PS backbone and densely grafted rod-like P3HT side chains were successfully synthesized by a combination of the quasiliving Grignard metathesis (GRIM) method, reversible addition–fragmentation chain transfer (RAFT), and click reaction. The molecular weight distribution of the resulting PS-g-P3HT copolymer...

Herein, we report a photoinitiated reversible addition-fragmentation chain transfer (RAFT) dispersion copolymerization of methyl methacrylate (MMA) and methyl methacrylic (MAA) for the preparation of highly monodisperse carboxyl-functionalized polymeric microspheres. High rates of polymerization were observed, with more than 90% particle yields being achieved within 3 h of UV irradiation. Effec...

Tight docking of the ribosome at the translocation channel ensures that nascent secretory proteins are shielded from the cytoplasm during transfer into the endoplasmic reticulum. Discrete pause transfer sequences mediate the transient stopping of translocation in certain proteins. Here we show that during a translocational pause, the junction between the ribosome and translocation channel is op...

2,3-Dichloro-1,4-naphthoquinone and tetrabromoor tetrachloro-1,4-benzoquinone were converted into pyridinium enolate betaines by reaction with pyridine or 4,4′-bipyridine. The reaction conditions were applied to poly-(4-vinylpyridine) and a modified Merrifield resin to obtain functionalized polymeric materials. These were examined in thermogravimetric analyses. Reversible photocatalytic electro...

Synthesis of core-shell nanoparticles by surface initiated reversible addition fragmentation chain transfer polymerization in presence of a chiral template conjugated to magnetic nanoparticles is reported. The approach leads to imprinted nanoparticles featuring enantioselectivity and enhanced affinity compared to nanoparticles prepared using free template.

Homopolymers of N-acryloyl glycinamide were prepared by reversible addition-fragmentation chain transfer polymerization in water. The formed macromolecules exhibit strong polymer-polymer interactions in aqueous milieu and therefore form thermoreversible physical hydrogels in pure water, physiological buffer or cell medium.

β-Hairpin formation is one of the fundamental folding actions in biomacromolecules. We present a linear triblock copolymer synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, that is able to mimic on a very basic level hairpin formation by using π-π stacking interactions between phenyl and 2,3,4,5,6-pentafluorophenyl residues.