purpose:  to evaluate the significance of the presence of pigment granules in  the anterior  vitreous as a reliable indicator of retinal breaks in patients with acute symptomatic posterior vitreous detachment  (pvd) . methods: this cross sectional study included 209 phakic patients with acute symptomatic pvd. the patients underwent anterior vitreous examination and fundoscopy. patients with dia...

Introduction: Cervical cancer is the fourth most common cancer of women worldwide. It spreads either by local invasion or by hematogenous spread. Metastases to the eye, intraocular metastasis have been reported but they are uncommonly seen. Choroidal secondaries are the most common intraocular malignancies in adults, metastasis to the choroid from utero-cervical carcinoma are an exceedingly rar...

introduction: breast cancer is the second most common cause of brain metastasis. although patient prognosis is poor, isolated brain metastasis occasionally can be an option for treatment with curative intent in breast cancer patients. case presentation: we report a patient with invasive ductal carcinoma of the breast who developed an isolated right frontal lobe metastasis within 5 months of fin...

purpose: to compare the anatomical results of scleral buckling with or without retinopexy and to assess the effect of retinopexy on outcomes of the operation.  methods: this interventional case series was performed on 22 patients undergoing scleral buckling (segmental or encircling) with or without subretinal fluid drainage and without any type of retinopexy and 33 patients who received transsc...

purpose: to evaluate the rate of optical coherence tomography (oct) grid decentration in a routine practice and its effect on thickness measurements methods: topcon spectral domain oct scans from various macular diseases including age related macular degeneration, diabetic macular edema, macular pucker and central serous chorioretinopathy (cscr) were studied in all patients visited during seven...

We had demonstrated that plasminogen kringle 5 (K5), a potent angiogenic inhibitor, inhibited retinal neovascularization and hepatocellular carcinoma growth by anti-angiogenesis. The current study investigated the effects and the underlying mechanisms of K5 on both tumor growth and spontaneous pulmonary metastasis in Lewis lung carcinoma (LLC) implanted mouse model. Similarly, K5 could decrease...

Clinical outcomes for high-risk neuroblastoma patients remains poor, with only 40-50% 5-Year overall survival (OS) and <10% long-term survival. The ongoing acquisition of genetic/molecular rearrangements in undifferentiated neural crest cells may endorse neuroblastoma progression. This study recognized the loss of Retinal Degeneration protein 3, RD3 in aggressive neuroblastoma, and identified i...

Renal medullary carcinoma (RMC) is a rare, aggressive primary renal malignancy that classically occurs in adolescent males with sickle cell trait and universally presents with metastatic disease at presentation. We report a case of medullary carcinoma in a young man with likely ophthalmic metastasis. We also review relevant literature available to date. The patient is a 20-year-old African-Amer...

  Myxoid is a common type of liposarcoma. Cardiac metastasis of sarcoma is a rare diagnosis. Transthoracic echocardiography is a useful tool for beginning the diagnosis. Curative resection of metastasis and then combination systemic chemotherapy for advanced disease is recommended. We report a 50 year old woman who presented with a cardiac metastasis of high grade round cell liposarcoma to righ...