Background—Platelets play a central role in the process of restenosis after percutaneous coronary interventions. A polymorphism of platelet glycoprotein IIIa (Pl) has been associated with a higher risk of coronary thrombosis. We designed this prospective study to test the hypothesis that Pl polymorphism of glycoprotein IIIa is associated with an increased risk for restenosis after coronary sten...

BACKGROUND The efficacy of drug-eluting stents in reducing restenosis risk has not been uniform across patient subsets. Identifying predictive factors of restenosis may help improve outcomes after percutaneous coronary interventions. METHODS AND RESULTS All patients who underwent successful implantation of sirolimus- or paclitaxel-eluting stents in native vessels for de novo lesions between A...

BACKGROUND Several metallic intracoronary stents are currently undergoing preliminary evaluation to ascertain potential benefit as means to reduce the 30-40% incidence of restenosis after balloon angioplasty. METHODS AND RESULTS To determine the incidence and correlates of restenosis after placement of Palmaz-Schatz stents in native coronary arteries in the first group of patients selected fo...

OBJECTIVES This study was performed to determine predictors of in-stent restenosis from a high volume, single-center practice. BACKGROUND Intracoronary stents have been shown to reduce the restenosis rate as compared with balloon angioplasty, but in-stent restenosis continues to be an important clinical problem. METHODS Between April 1993 and March 1997, 1,706 patients with 2,343 lesions we...

OBJECTIVES The purpose of this study was to assess the accuracy of a new generation spiral multidetector computed tomography (MDCT) scanner (Brilliance 40, Philips Medical Systems, Cleveland, Ohio) in the diagnosis of coronary in-stent restenosis (ISR). BACKGROUND Noninvasive imaging of ISR would be clinically useful, but artifacts caused by metallic stent struts have limited the role of earl...

OBJECTIVES We investigated the incidence and predictors of recurrent restenosis after drug-eluting stent (DES) implantation for in-stent restenosis (ISR) in routine clinical practice. BACKGROUND Although DESs have been increasingly used for treatment of ISR, little is known about the predictors of DES failure. METHODS We determined the incidence of recurrent restenosis and major adverse car...

OBJECTIVES This study was designed to analyze the in-hospital and six-month clinical and angiographic outcomes of patients with chronic renal failure (CRF) treated with intracoronary radiation for the prevention of recurrence of in-stent restenosis. BACKGROUND Patients with CRF are at a higher risk than the general population for accelerated atherosclerotic cardiovascular disease and for rest...

A prospective, multicenter, cohort study from Italy December 2016 to 2018. For 287 patients with chronic limb-threatening ischemia (CLTI) who underwent open, endovascular, or hybrid lower extremity revascularization, the 30-day major adverse cardiovascular and limb events (MALE) rates were 3% 2%, respectively. At 1 year, overall survival, amputation-free freedom MALE, primary patency rate was 8...

With Restenosis After Percutaneous Coronary Intervention To the Editor: High levels of osteopontin (OPN) mRNA and proteins were reported in atherosclerotic plaques.1,2 Recently, we reported plasma OPN levels to be high in patients with coronary artery disease (CAD) and to correlate with the severity of CAD.3 However, no association between plasma OPN levels and restenosis after percutaneous cor...

OBJECTIVES Restenosis following remote superficial femoral artery endarterectomy (RSFAE) remains a challenging problem. The determinants predicting failure are lacking. This study investigated patient characteristics with predictive value for restenosis during the first year after RSFAE. DESIGN A prospective cohort study. MATERIALS AND METHODS A total of 90 patients post-RSFAE were studied ...