Nisin is a bacteriocin approved in more than 50 countries as a safe natural food preservative. Response surface methodology (RSM) combined with artificial neural network-genetic algorithm (ANN-GA) was employed to optimize the fermentation medium for nisin production. Plackett-Burman design (PBD) was used for identifying the significant components in the fermentation medium. After that, the path...

Resveratrol (RV), a dietary antioxidant polyphenolic compound found in grapes and red wine, exerts a wide variety of pharmacological activities. However, lower content in plants compared with polydatin (PD, the glucoside of RV) limits its application in the food and pharmaceutical industries. In this paper, we carried out efficient biotransformation of PD to RV with 100% conversion yield by sna...

Optimum conditions for extracting total phenolic compounds (TPC) and antioxidant activity from fresh dark fig (Ficus carica L.) have been investigated using response surface methodology (RSM). The Box-Behnken design was used to investigate the effects of three independent variables, acetone concentration (40-80%), temperature (25-65 °C), and time (60-120 min), on the response. Regression analys...

This paper presents the modeling and design of an actuator consisting of an electrical motor and a magnetic gear. To minimize the overall actuator dimensions, both of the electromagnetic devices need to be optimally designed and matched. An issue in performing a simultaneous design as such arises from a high number of design variables that significantly increases the complexity of the optimizat...

In this paper, ultrasound-assisted extraction (UAE) was applied to the extraction of anthraquinones (aloe-emodin, rhein, emodin, chrysophanol and physcion) from Rheum palmatum L. The five anthraquinones were quantified and analyzed by high performance liquid chromatography coupled with UV detection (HPLC-UV). The extraction solvent, extraction temperature and extraction time parameters, the thr...

Artificial neural networks (ANN) and response surface methodology (RSM) were used to build a model to describe the effects of four independent variables (moisture content, concentrations of glucose, ammonium nitrate and methionine) on the yield of cephalosporin C (CPC) from Acremonium chrysogenum under solid state fermentation. The respective uses of RSM and ANN were found to be effective in lo...

the present study presents an algorithm that models uncertainties at the structural component level to estimate the performance reliability of rc structures. the method calculates the performance reliability using a systemic approach and incorporates the improved response surface method based on sampling blocks using the first-order reliability method and conditional reliability indices. the re...

this study determined optimum conditions for drying pomegranate arils in a solar dryer. a cabinet solar dryer was used in active and mixed modes. the response surface method was employed with nine treatments (runs) and a control run (3 m/s air velocity and 2 cm in thickness) and five replications. the bryte cultivar was tested and samples were dried to approximately 10% moisture. drying time, v...

The introduction on large scale of high strength materials in automotive industry provided the possibility to reduce weight and produce safer cars. But at the same time these materials yield more springback than deep drawing steels. This can lead to problems designing the right tools for the forming process. This paper presents a method for the optimization of sheet metal forming parameters in ...