Extracellular NAD induces the ATP-independent activation of the ionotropic P2X(7) purinergic receptor (P2X(7)R) in murine T lymphocytes via a novel covalent pathway involving ADP-ribosylation of arginine residues on the P2X(7)R ectodomain. This modification is catalyzed by ART2.2, a GPI-anchored ADP-ribosyltransferase (ART) that is constitutively expressed in murine T cells. We previously repor...

To study the expression of the I factor, a non-long-terminal-repeat retrotransposon responsible for I-R hybrid dysgenesis in Drosophila melanogaster, we have tagged the ORF1 protein (ORF1p) by inserting the HA epitope in its N-terminal region. In transgenic flies, this modification is compatible with a high rate of autonomous transposition and allows direct estimation of the transposition frequ...

We consider a modification of gravity at large distances in a Brane Universe which was discussed recently [1–4]. In these models the modification of gravity at large distances is ultimately connected to existence of negative tension brane(s) and exponentially small tunneling factor. We discuss a general model which interpolates between Bi-gravity +−+ model [1] and GRS model [2]. We also discuss...

Rck2, a yeast Ser/Thr protein kinase homologous to mammalian calmodulin kinases, requires phosphorylation for activation. We provide evidence that in budding yeast, this step can be executed by the osmostress-activated mitogen-activated protein kinase Hog1. Rck2 phosphorylation was transiently increased during osmostress or in mutants with a hyperactive high osmolarity glycerol (HOG) pathway. T...

Outdoor electronic equipment such as signal stations, radar units, and cellular base stations would benefit from electromagnetic interference (EMI) shielding systems, but ice accretion on the surface of these facilities often causes critical challenges, especially in cold regions winter season. In this study, icephobic nanocomposite electrospun membranes were developed via a two-step process re...

A bstract We study inclusive jet suppression and modifications in the quark-gluon plasma (QGP) with a transport-based model. The model includes vacuum-like parton shower evolution at high-virtuality, linearized transport for jet-medium interactions, simple ansatz jet-induced hydrodynamic response of medium. Model parameters are calibrated to nuclear modification factors hadron $$ {R}_{AA}^h <mm...

the management of carotid artery stenosis reduces the risk of stroke and its related deaths.   management options include risk factor modification and medical therapy, carotid endarterectomy (cea), and carotid artery stenting (cas). although several randomized controlled trials (rcts), mostly conducted in late-1980s and mid-1990s, have proved cea to be effective in the prevention of ipsilateral...

reaching an electricity system which is both economically efficient and environmentally friendly is motivating countries to design and execute different types of tou demand response programs. but there are certain deficiencies which prevent these programs to effectively modify the load shape. smart grid as a means could help the electricity system to reach the highest demand side management ...