OBJECTIVE The transcription factor early growth response (EGR)-1 has been implicated as a key vascular phenotypic switch through its control of inducible transcription. EGR-1 autoregulation, and histone modification in the EGR-1 promoter, represent key mechanisms in EGR-1 control, but have not been explored. METHODS AND RESULTS We demonstrate that EGR-1 regulates its own transcription and tha...

Although, experimental studies have reported fracture at the corner of Steel Plate Shear Walls (SPSW), no study has been performed to investigate the crack effect, yet. Therefore, in this paper, the effect of crack at the corner of SPSWs on the seismic behavior of the system was investigated. Two probable cracks, that have been studies at the corner of SPSWs utilizing extended Finite Element me...

Diminishing protein aggregation by chaperone is very important factor in medicine and industry. In this paper, itis induced the chaperone ability for 0-casein upon modification of its acidic residues by Woodward reagentK(WRK) and examined on lysozyme as a target protein at pH 7.2 and outlined the mechanism for chaperoneability of modified system by UV-Vis and fluorescence spectroscopy and theor...