Hantaviruses (family Bunyaviridae, genus Hantavirus) are rodent-borne zoonotic viruses that produce two major clinical syndromes in humans: haemorrhagic fever with renal syndrome in Asia and Europe and hantavirus pulmonary syndrome (HPS) in the Americas. Since HPS was initially characterised in the United States of America (USA) in 1993 and since the associated hantavirus Sin Nombre virus (SNV)...

Next generation sequencing has now enabled a cost-effective enumeration of the full mutational complement of a tumor genome-in particular single nucleotide variants (SNVs). Most current computational and statistical models for analyzing next generation sequencing data, however, do not account for cancer-specific biological properties, including somatic segmental copy number alterations (CNAs)-w...

the potential of fourier transform near-infrared (ft-nir) spectroscopy technique was applied to determine moisture and soluble solids content of shahani date fruit. spectral acquisitions were carried out in reflectance mode using a ft-nir spectrophotometer in the range of 12000- 4000cm-1. three different preprocessing methods namely: multiplicative scatter correction (msc), first and second der...

The possibility of basing cryptography on the minimal assumption NP * BPP is at the very heart of complexity-theoretic cryptography. The closest we have gotten so far is lattice-based cryptography whose average-case security is based on the worst-case hardness of approximate shortest vector problems on integer lattices. The state-of-the-art is the construction of a one-way function (and collisi...

Evasion of interferon (IFN)-mediated antiviral signaling is a common defense strategy for pathogenic RNA viruses. To date, research on IFN antagonism by hantaviruses is limited and has focused on only a subset of the numerous recognized hantavirus species. The host IFN response has two phases, an initiation phase, resulting in the induction of alpha/beta IFN (IFN-α/β), and an amplification phas...

Systemic necrotizing vasculitis (SNV) is a type of vasculitis that presents with necrosis, predominantly involving large, medium-sized and small arteries. Peripheral neuropathy is a major clinical feature of the primary and secondary systemic vasculitides, and is often observed during the early phases of the disease, causing axonal neuropathy. The prevalence of central nervous system (CNS) invo...

The 5' long terminal repeat (LTR) of spleen necrosis virus (SNV) contains a unique posttranscriptional control element that facilitates Rev/Rev-responsive element-independent expression of unspliced human immunodeficiency virus type 1 (HIV-1) gag reporter RNA. HIV-1 Gag expression is eliminated when SNV LTR is repositioned to the 3' untranslated region or when the RU5 region is positioned in th...

This article presents a probabilistic logic whose sentences can be interpreted as asserting the acceptability of gambles described in terms of an underlying logic. This probabilistic logic has a concrete syntax and a complete inference procedure, and it handles conditional as well as unconditional probabilities. It synthesizes Nilsson’s probabilistic logic and Frisch and Haddawy’s anytime infer...

Deoxyribonucleoside triphosphate (dNTP) pool imbalances are associated with an increase in the rate of misincorporation and hypermutation during in vitro reverse transcription reactions. However, the effects of in vivo dNTP pool imbalances on the accuracy of reverse transcription are unknown. We sought to determine the effects of in vivo dNTP pool imbalances on retroviral mutation rates and to ...