A practical protocol is developed to directly provide chiral α-acyloxyphosphonates and α-hydroxyphosphonates from (±)-α-hydroxyphosphonates utilizing the transacylation process to generate the mixed anhydrides from acid components and pivalic anhydride in the presence of organocatalysts (s-value = 33-518).

INTRODUCTION................................................... 492 The Cast of Characters ................................................... 492 Dispersal of Alphaviruses................................................... 494 Full-Length Clones of Alphaviruses ................................................... 494 STRUCTURE OF ALPHAVIRUSES ................................................... ...

Keratinocytes protect themselves from UV-induced damage and death by signalling to melanocytes produce transfer melanin their nuclei further UV damage. The keratinocyte-melanocyte communication axis defines the tanning response, which is integral epidermal homeostasis. We studied effects of occasional, moderate chronic UVA/UVB exposure on keratinocytes in vitro using immortalised human monocult...

Methods: Case-control observational study of 518 people in western Santa Catarina, including 259 patients diagnosed with CM between 2002 and 2012, and 259 age-, sex, and residence-matched controls. Pigmentation characteristics, presence and size of nevi and history of cutaneous neoplasia, sun exposure, and sunburn were evaluated. Data were subjected to univariate and multiple logistic regressio...

OBJECTIVE Our objective was to evaluate the performance of a computer-aided detection (CAD) system for pulmonary nodule detection using low-dose screening CT images. MATERIALS AND METHODS One hundred fifty consecutive low-dose screening CT examinations were independently evaluated by a radiologist and a CAD pulmonary nodule detection system (R2 Technology) designed to identify nodules larger ...

Deletion of F508 in the first nucleotide binding domain (NBD1) of cystic fibrosis transmembrane conductance regulator protein (CFTR) is the commonest cause of cystic fibrosis (CF). Functional interactions between CFTR and CK2, a highly pleiotropic protein kinase, have been recently described which are perturbed by the F508 deletion. Here we show that both NBD1 wild type and NBD1 DeltaF508 are p...

We produce several public void catalogs using a volume-limited subsample of the Sloan Digital Sky Survey Data Release 7 (SDSS DR7). Using new implementations three different void-finding algorithms, VoidFinder and two ZOBOV-based algorithms (VIDE REVOLVER), we identify 1163, 531, 518 cosmic voids with radii >10 Mpc/h, respectively, out to redshift z = 0.114 assuming Planck 2018 cosmology, 1184,...