UNLABELLED The adenosine triphosphate-binding cassette transporters P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) are 2 major gatekeepers at the blood-brain barrier (BBB) that restrict brain distribution of several clinically used drugs. In this study, we investigated the suitability of the radiolabeled Pgp/BCRP inhibitors (11)C-tariquidar and (11)C-elacridar to assess Pgp de...

UNLABELLED A rapid, reliable method for distinguishing tumors or metastases that overexpress human epidermal growth factor receptor 2 (HER2) from those that do not is highly desired for individualizing therapy and predicting prognoses. In vivo imaging methods are available but not yet in clinical practice; new methodologies improving speed, sensitivity, and specificity are required. METHODS A...

New data on the fatty acid compositions of muscle tissues two most widespread families mesopelagic zone—the Myctophidae (Notoscopelus kroyeri and Symbolophorus veranyi) Stomiidae (Chauliodus sloani, Stomias boa, Borostomias antarcticus, Malacosteus niger) families—were obtained from Irminger Sea (North East Atlantic). The acids (FAs) in total lipids (TLs), phospholipids (PLs), triacylglycerols ...

the δ18o, δ13c, and strontium/calcium (sr/ca)-record was measured from a 7-year old platygyrasinensis coral located offshore larak island in the persian gulf at a resolution of 22 samples/year. an increasedsampling resolution of 55 samples/year over two annual cycles was also compared with the 22 sampleresolution to evaluate the effectiveness of the sampling procedure. the resulting data exhibi...

Purpose: To directly compare HRRT (high resolution brain) and HR+ (standard wholebody) PET only scanners for quantitative brain studies using three tracers with vastly different tracer distributions. Procedures: Healthy volunteers underwent successive scans on HR+ and HRRT scanners (in random order) using either (R)-[C]verapamil (n=6), [C]raclopride (n=7) or [C]flumazenil (n=7). For all tracers...

This study aims at developing a simulation system that predicts the optimal study design for attaining tracer steady-state conditions in brain and blood rapidly. Tracer kinetics was determined from bolus studies and used to construct the system. Subsequently, the system was used to design inputs for bolus infusion (BI) or programmed infusion (PI) experiments. Steady-state quantitative measureme...

We develop an approach to utilize anisotropic metamaterials to solve one of the fundamental problems of modern plasmonics--parasitic scattering of surface waves into free-space modes, opening the road to truly two-dimensional plasmonic optics. We illustrate the developed formalism on the examples of plasmonic refractor and plasmonic crystal, and discuss limitations of the developed technique an...

The pontine nuclei (PN) receive projections from the auditory cortex (AC) and they are a major source of mossy fibers to the cerebellum. However, they have not been studied in detail using sensitive neuroanatomical tracers, and whether all AC areas contribute to the corticopontine (CP) system is unknown. We characterized the projection patterns of 11 AC areas with WGA-HRP. We also compared them...