Tumefactive demyelinating lesions or tumefactive multiple sclerosis (TMS) constitute a unique presentation of demyelinating disease that frequently mimics intracranial neoplasm, infection or other, nondemyelinating intracranial pathology. Consequently, these lesions, which are larger than typical multiple sclerosis plaques and are generally characterized by certain MRI features including edema ...

Background and objective: Magnetic resonance imaging (MRI) is the most sensitive technique to detect multiple sclerosis (MS) plaques in central nervous system. In some cases, the patients who were suspected to MS, Whereas MRI images are normal, but whether patients don’t have MS plaques or MRI images are not enough optimized enough in order to show MS plaques? The aim of the current study is ...

Multiple Sclerosis (MS) is an inflammatory and demyelization disease that causes the disorder of the central nervous system. Magnetic resonance imaging (MRI) becomes the most important means for a better understanding of the disease. A variety of methods to segment these lesions are available to make the lesions detection less fastidious. So, we use a robust algorithm on EM algorithm that propo...

OBJECTIVE To determine non-invasively the relation between the degree of axonal loss and the extent of demyelination in chronic lesions visible on MRI in patients with different subgroups of clinically definite multiple sclerosis using (1)H magnetic resonance spectroscopy ((1)H MRS) and magnetisation transfer imaging (MT). Conventional MRI is unable to differentiate between the various patholog...

Changes in iron concentration in brain tissue are of interest in the study of neurodegenerative diseases such as Alzheimer’s and multiple sclerosis [MPY13]. Magnetic resonance imaging (MRI) is inherently sensitive to changes in tissue magnetic susceptibility, which can be used as a direct measure of iron concentration [Sch96]. Changes in tissue magnetic susceptibility result in phase shifts in ...

Submit Manuscript | http://medcraveonline.com Abbreviations: α-syn: α-synucleinopathies; Aβ: Amyloid Beta; AD: Alzheimer’s Disease; ALL: Acute Lymphoblastic Leukemia; ALS: Amyotrophic Lateral Sclerosis; BBB: Blood Brain Barrier; BPB: Brain Protective Barriers; CAR: Chimeric Antigen Receptor; CLL: Chronic Lymphocytic Leukemia; CNS: Central Nervous System; CSF: Cerebro-Spinal Fluid; CTLA: Cytotox...

In relapsing-remitting (RR) multiple sclerosis (MS), conventional magnetic resonance (MR) imaging (MRI) has proved to be a valuable tool to assess the lesion burden and activity over time. However, conventional MRI cannot characterize and quantify the tissue damage within and outside such lesions and only can provide some gross measures reflecting the presence of irreversible tissue damage, suc...

In established multiple sclerosis, magnetization transfer ratio (MTR) histograms reveal abnormalities of normal-appearing white matter (NAWM) and grey matter (NAGM). The aim of this study was to investigate for such abnormalities in a large cohort of patients presenting with clinically isolated syndromes suggestive of multiple sclerosis. Magnetization transfer imaging was performed on 100 patie...

OBJECTIVE A case with sudden sensorineural hearing loss (SSNHL) owing to multiple sclerosis (MS) who had clinical and dramatic radiological improvement just after medical therapy was reported in this article. METHOD Case report and review of related literature. RESULTS A 22-year-old female patient with MS related SSNHL was presented in this article. Magnetic resonance imaging (MRI) revealed...

We report the case of a 42-year-old woman with a slowly progressive cerebellar syndrome. In contrast to a relatively mild clinical presentation, the magnetic resonance imaging (MRI) showed extensive leukencephalopathy with cystic degeneration. Initially primary progressive multiple sclerosis (PPMS) was suspected. Additional diffusion-weighted imaging revealed restricted diffusion in the white m...