Xiao Chai Hu Tang (XCHT), a traditional herbal formula, is widely administered as a cancer treatment. However, the underlying molecular mechanisms of its anticancer effects are not fully understood. In the present study, a computational pharmacological model that combined chemical space mapping, molecular docking and network analysis was employed to predict which chemical compounds in XCHT are ...

The caatinga, an exclusively Brazilian biome, is one of the most endangered vegetation systems in the planet. To be exploited rationally, its potential needs to be scientifically demonstrated. Among these is the faveleira, used in northeastern Brazil. It stands out for its extraordinary drought resistance and medicinal properties. The objective of this study was to assess the therapeutic potent...

romusn ~? sll'Phanilamide during the years. was made in the efforts to find a chemical compound which is active against the pneumococcal*. lany previous allied compounds had been ma e vmch were active against pneumococci, bu *ere too toxic for clinical use. This new comp?und, labelled M. and B. 693, was finally chosen because of its high activity and low toxicity the most satisfactory 'therapeu...

Safety risk study on road transportation of hazardous chemicals is a reliable basis for the government to formulate transportation planning and preparing emergent schemes, but also is an important reference for safety risk managers to carry out dangerous chemicals safety risk managers. Based on the analysis of the transport safety risk of dangerous chemicals at home and abroad, this paper studi...

A review is presented of some of the factors affecting the laboratory testing and practical applications of chemicals toxic to algae. The basic factor demonstrated is that the amount of chemical required to inhibit the growth of algae is dependent on the amount of algae present and not on the volume of water in which the algae are dispersed. It is shown how a chemical can be tested for algistat...

while the oecd test guidelines and mostly animal assays have been used to study the toxic effects of chemicals for many years, very little is known about the potential toxicity of vast majority of inhaled chemicals. considering large number of chemicals and complex mixtures present in indoor and outdoor air, heavy reliance on animal test methods appear to be not adequate. continuing scientific ...

Plant secondary (or specialized) metabolites determine multitrophic interaction dynamics. Herbivore natural enemies exploit plant volatiles for host location and are negatively affected by defense chemicals that transferred through herbivores. Recent work shows herbivore can evolve resistance to chemicals, generating forward evolution enhances their capacity prey on Here, we discuss how this kn...